Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom

Occupational and Environmental Medicine
A ReidN de Klerk

Abstract

The presence of asbestos in public buildings is a legacy of past asbestos use in many developed countries. Of particular concern is the amount and current condition in schools and the vulnerability of children to mesothelioma. Our aim was to compare the risk of mesothelioma between those exposed to blue asbestos as children and as adults at Wittenoom. Public sources were used to establish the Wittenoom residents' cohort. Mesothelioma incidence rates per 100 000 person-years at risk were derived for those first exposed to asbestos at Wittenoom as children (<15 years) or adults separately. Proportional hazards survival models examined the slope of the exposure-response relationship between asbestos exposure and incidence of mesothelioma in different sex and age groups. The mesothelioma rate was lower among those first exposed as children (76.8 per 100 000) than those first exposed as adults (121.3 per 100 000). Adjusting for cumulative exposure to asbestos and sex, those exposed as adults had a greater risk of mesothelioma (adjusted HR 2.5, 95% CI 1.7 to 3.7). The slope of the exposure-response relationship did not differ between those exposed as children and those exposed as adults. We found no greater susceptibility to mesothel...Continue Reading

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Citations

Nov 2, 2019·International Journal of Epidemiology·Arthur W Bill MuskNicholas de Klerk
Apr 1, 2019·Occupational and Environmental Medicine·Alison ReidNicholas H de Klerk
Feb 11, 2021·International Journal of Environmental Research and Public Health·Edward A Emmett
Oct 14, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daniel OrbachMyriam Ben Arush
Dec 28, 2021·Pediatric Blood & Cancer·Miriam Santiago KimpoKrishnan Prabhakharan

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