PMID: 9527181Apr 4, 1998Paper

Are circulating adhesion molecules specifically changed in cardiac surgical patients?

The Annals of Thoracic Surgery
J BoldtG Hempelmann

Abstract

Soluble adhesion molecules are considered to be markers of inflammation, endothelial activation, or damage. This study was designed to assess whether adhesion molecules are specifically altered in patients undergoing cardiac surgical procedures. Three groups of 20 patients each were prospectively studied: patients undergoing elective coronary artery bypass grafting; patients scheduled for a Whipple pancreatoduodenectomy; and patients undergoing elective pneumonectomy for lung cancer. Plasma levels of soluble adhesion molecules (endothelial leukocyte adhesion molecule-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and granule membrane protein 140) were measured from arterial blood samples after induction of anesthesia (baseline), at the end of the operation, 2 hours and 5 hours after operation, and on the morning of the first postoperative day. Duration of operation was longest in the group having a Whipple operation (289 +/- 50 minutes) and did not differ between the other two groups. Plasma levels of all measured adhesion molecules at baseline were within normal ranges. After cardiopulmonary bypass, levels of adhesion molecules were significantly increased in the cardiac surgical patients (soluble end...Continue Reading

References

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Apr 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·J BoldtG Hempelmann

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Citations

Jan 17, 2004·The Annals of Thoracic Surgery·Hilde EikemoVibeke Videm
May 9, 2000·The Annals of Thoracic Surgery·Z L CaoT Itoh
Mar 29, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Yavuz EncSükran Sahin
May 11, 2002·Critical Care Medicine·Konrad ReinhartMichael Meisner
Mar 5, 2008·Pediatric Research·Melinda E LullAkif Undar
Jun 5, 2007·The Journal of International Medical Research·C OzkaraS Ozcan
Jun 17, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J GrünenfelderM Turina
Jul 31, 2004·Clinical Science·Ruksana HudaMali Mathru
Mar 28, 2020·Cardiovascular Research·Elena V DolmatovaKathy K Griendling

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