Are comorbid anxiety disorders a risk factor for suicide attempts in patients with mood disorders? A two-year prospective study

European Psychiatry : the Journal of the Association of European Psychiatrists
Lena Nabuco de AbreuBeny Lafer

Abstract

Comorbid anxiety disorders have been considered a risk factor for suicidal behavior in patients with mood disorders, although results are controversial. The aim of this two-year prospective study was to determine if lifetime and current comorbid anxiety disorders at baseline were risk factors for suicide attempts during the two-year follow-up. We evaluated 667 patients with mood disorders (504 with major depression and 167 with bipolar disorder) divided in two groups: those with lifetime comorbid anxiety disorders (n=229) and those without (n=438). Assessments were performed at baseline and at 3, 12, and 24 months. Kaplan-Meier survival analysis and log-rank test were used to evaluate the relationship between anxiety disorders and suicide attempts. Cox proportional hazard regression was performed to investigate clinical and demographic variables that were associated with suicide attempts during follow-up. Of the initial sample of 667 patients, 480 had all three follow-up interviews. During the follow-up, 63 patients (13.1%) attempted suicide at least once. There was no significant difference in survival curves for patients with and without comorbid anxiety disorders (log-rank test=0.269; P=0.604). Female gender (HR=3.66, P=0.00...Continue Reading

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Citations

Mar 27, 2020·Psychiatry Investigation·Laura OrsoliniDomenico De Berardis
Jun 22, 2020·Psychiatry Research·Andras N ZsidoSzabolcs A Bandi
Feb 1, 2022·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·César NúñezVicente E Caballo

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