Are Contact Lens Discomfort or Soft Contact Lens Material Properties Associated with Alterations in the Corneal Sub-Basal Nerve Plexus?

Current Eye Research
Alberto López-de la RosaMaría J González-García

Abstract

To study whether contact lens (CL) discomfort and some properties of soft CL materials are associated with alterations in the nerve fibers morphology and density of dendritic cells of the corneal sub-basal nerve plexus. Forty soft CL wearers and 20 non-CL wearers were included. The Contact Lens Dry Eye Questionnaire-short form was administered to divide CL wearers based on their symptoms (20 symptomatic and 20 asymptomatic CL wearers were included). The CL material properties considered were the CL material type (16 hydrogel and 24 silicone hydrogel CL wearers were included), water content, oxygen transmissibility, and modulus of elasticity. Confocal microscopy was performed, and the number and density of corneal nerves, density of nerve branches, grade of nerve tortuosity, and density of dendritic cells were analyzed. The effects of CL discomfort and CL material properties on the confocal microscopy parameters were analyzed. No significant differences were found among symptomatic and asymptomatic CL wearers and non-CL wearers in any of the confocal microscopy parameters evaluated. The density of dendritic cells was higher in the hydrogel CL wearers compared to the silicone hydrogel CL wearers and non-CL wearers (p = 0.002). Th...Continue Reading

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Citations

Nov 15, 2019·Cornea·Noor Haziq SalimanCarole Maldonado-Codina
Sep 16, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Vivien TseMeng C Lin
Dec 8, 2019·Journal of Clinical Medicine·Amaya Pérez Del PalomarTanima Bose
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Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Fiona StapletonJames S Wolffsohn
May 20, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Andrea Novo-DiezMaría Jesús González-García
Jul 21, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Noor Haziq SalimanPhilip B Morgan
Aug 28, 2021·Diagnostics·Pilar CañadasMargarita Calonge

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