Are drugs taken as prescribed?

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Ingrid HovOlav Spigset

Abstract

The term "adherence" is used to describe whether drugs are taken as prescribed. This article outlines what is known about adherence for several central drug classes, which factors modify adherence, the consequences of low adherence and how adherence can be improved. We reviewed a selection of studies of adherence for the following seven drug classes: antidiabetics, antiepileptics, antihypertensives, statins, psychotropic drugs, antibiotics and analgesics. For antidiabetics, the proportion of patients with high adherence varied between 31 % and 80 % in the different studies. The corresponding figures for the other drug classes were: antiepileptics, 61-74 %; antihypertensives, 23-73 %; statins, 25-44 %; psychotropic drugs, 21-80 %; antibiotics, 41-70 % and analgesics, 41-53 %. As a general rule, adherence declined with time. For serious diseases, a decline in adherence led to a worsening of symptoms and an increased risk of hospitalisation and death. Dosing once daily proved to result in higher adherence than multiple daily dosing. Complex therapy regimes, depression, impaired cognitive function, side effects and inadequate follow-up reduce adherence. It is important to achieve high adherence, not least for serious diseases. In o...Continue Reading

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Citations

Sep 5, 2014·International Journal of Clinical Pharmacy·Helle HåkonsenElse-Lydia Toverud
Feb 21, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Roar Dyrkorn, Pål-Didrik Hoff Roland
Oct 13, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Frode EdvardsenArne Helland
Oct 13, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Halvor LundgaardOlav Spigset
Oct 19, 2012·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Lars Slørdal

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