Are Enterocolic Mucosal Mast Cell Aggregates Clinically Relevant in Patients Without Suspected or Established Systemic Mastocytosis?

The American Journal of Surgical Pathology
Melanie JohncillaRhonda K Yantiss

Abstract

The World Health Organization considers enterocolic mast cell aggregates with atypical morphologic and/or immunohistochemical features diagnostic of systemic mastocytosis mostly because published data are heavily influenced by inclusion of symptomatic patients with systemic disease. We occasionally encounter atypical mast cells in gastrointestinal biopsy samples from patients in whom systemic mastocytosis is not suspected. The aim of this study was to describe the clinicopathologic features and implications of atypical enterocolic mast cell aggregates in 16 patients without suspected or established systemic mastocytosis. Mast cell infiltrates were assessed for morphology, distribution, associated inflammatory cells, and CD117 and CD25 immunoexpression. Most (63%) patients were women; 15 underwent endoscopic examination for screening (n=7), abdominal pain (n=3), diarrhea (n=3), changing bowel habits (n=1), and dysphagia (n=1). Mast cell aggregates were detected in 1 colectomy specimen for cancer. Colonic involvement was most common (n=14) and resulted in polypoid (n=10), edematous (n=2), or normal (n=3) mucosae. All cases featured CD117/CD25, ovoid mast cells concentrated beneath the epithelium, or diffusely involving the entire...Continue Reading

References

May 1, 1989·American Journal of Clinical Pathology·B V KettelhutD D Metcalfe
Sep 1, 1988·Gastroenterology·J A ChernerD D Metcalfe
Jul 26, 2000·Hematology/oncology Clinics of North America·R T Jensen
Aug 10, 2004·Gastroenterology·Jackie D Wood
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Mariana C Castells
Dec 7, 2007·The American Journal of Surgical Pathology·Hejin P Hahn, Jason L Hornick
Dec 20, 2014·Endoscopy·Shuji KochiTadahiko Fuchigami
Jul 9, 2016·Histopathology·Angela R ShihLawrence Zukerberg
Oct 21, 2016·American Journal of Hematology·Animesh Pardanani
Nov 26, 2016·Immunology and Allergy Clinics of North America·Anna Schuch, Knut Brockow
Jul 21, 2017·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali KomiStefan Wöhrl

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Citations

Oct 12, 2020·Gastroenterología y hepatología·Carmen Pradera CibreiroGema Molina Arriero
Jan 23, 2021·The American Journal of Surgical Pathology·Matthew J HamiltonOlga Pozdnyakova

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Methods Mentioned

BETA
biopsy

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