PMID: 36323Jan 1, 1979

Are epinephrine and gastrin accelerative factors of acute cinchophen ulcer?: Studies on gastric mucosal microcirculation and gastric secretion

Gastroenterologia Japonica
Y NagamachiN Akiyama

Abstract

Measurements of serum epinephrine and gastrin, simultaneously, gastric mucosal blood flow and gastric secretion were carried out in cinchophen treated dogs. No significant changes in either serum concentrations of epinephrine and gastrin or fundic mucosal microcirculation after a single 100 mg/kg cinchophen administration were found while gastric secretion increased markedly after the medication. On the other hand, a significant increase in serum epinephrine and gastrin levels was observed while gastric secretion decreased significantly after large doses of cinchophen (300 mg/kg) were injected intravenously. Here gastric mucosal microcirculation is decreased. Repeated administration of 100 mg/kg cinchophen for 3 to 7 days brought about an increase in epinephrine and gastrin levels and caused an occurrence of fundic mucosal hemorrhage. Sympathetic discharge and gastrin release were not seen after a 3-week period of cinchophen administration. Cinchophen ulcers were produced, even when contact between the bile and the stomach mucosa was avoided. Vagotomy had no connection with ulceration and gastric secretion.

Citations

Sep 1, 1977·The American Journal of Digestive Diseases·Y Nagamachi
Dec 1, 1970·The American Journal of Digestive Diseases·Y Nagamachi, K Ishihara
Oct 1, 1974·Archives of Surgery·L C WatsonJ C Thompson

Related Concepts

Gastric Juice
Gastric Ulcer
Mucositis
Quinolines
Structure of Pyloric Gland
Epinephrine Acetate
Gastrin
GAST
Microcirculation
Metazoa

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