Are ER+PR+ and ER+PR- breast tumors genetically different? A CGH array study

Cancer Genetics
Alma CarracedoFrancesc Solé

Abstract

The estrogen receptor (ER) is a well-known predictor of breast cancer response to endocrine therapy. ER+ progesterone receptor (PR)- breast tumors have a poorer response to endocrine therapy and a more aggressive phenotype than ER+PR+ tumors. A comparative genomic hybridization array technique was used to examine 25 ER+PR+ and 23 ER+PR- tumors. Tissue microarrays composed of 50 ER+PR+ and 50 ER+PR- tumors were developed to validate the comparative genomic hybridization array results. The genes of interest were analyzed by fluorescence in situ hybridization. The ER+PR- group had a slightly different genomic profile when compared with ER+PR+ tumors. Chromosomes 17 and 20 contained the most overlapping gains, and chromosomes 3, 8, 9, 14, 17, 21, and 22 contained the most overlapping losses when compared with the ER+PR+ group. The gained regions, 17q23.2-q23.3 and 20q13.12, and the lost regions, 3p21.32-p12.3, 9pter-p13.2, 17pter-p12, and 21pter-q21.1, occurred at different alteration frequencies and were statistically significant in the ER+PR- tumors compared with the ER+PR+ tumors. ER+PR- breast tumors have a different genomic profile compared with ER+PR+ tumors. Differentially lost regions in the ER+PR- group included genes with...Continue Reading

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Citations

Oct 16, 2015·Pediatric Blood & Cancer·Robert Tanner HagelstromPeter F Coccia
May 18, 2016·International Journal of Molecular Sciences·Simona GranataGianluigi Zaza
Oct 22, 2016·Cell Communication and Signaling : CCS·Susan M FarabaughAdrian V Lee
Oct 26, 2012·The New England Journal of Medicine·Clemens Tempfer

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