Are estrogens carcinogenic during development of the testes?

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
J A McLachlanM Negishi

Abstract

Many chemicals in the environment mimic the female sex hormone, estrogen. Exposure to environmental estrogens during early fetal development was proposed by Sharpe & Skakkebaek as a potential risk factor for subsequent testicular disease, including neoplasia and poor semen quality. To understand the mechanisms of action of estrogenic chemicals during differentiation of the male genital tract, we have studied developmental exposure to the synthetic estrogen, diethylstilboestrol (DES). While DES is a much more potent estrogen than most environmental chemicals examined, several of these compounds share some of the same properties as DES, such as a relative lack of binding to serum estrogen carrying proteins. Prenatal exposure to DES is associated with poor semen quality, prostatic disease, cryptorchidism and testicular neoplasia in mice. A rare form of testicular cancer, rete testis carcinoma, was observed in five percent of male mice treated in utero with DES. We also demonstrated altered regulation of an estrogen responsive gene, lactotransferrin (LTF) in the seminal vesicles of treated mice, but not the controls. Likewise, LTF was irreversibly altered in the uteri of developmentally treated females; at the molecular level alter...Continue Reading

References

Dec 1, 1987·The Journal of Urology·R R NewboldJ A McLachlan
Mar 11, 1983·JAMA : the Journal of the American Medical Association·G R ConleyH D Mitcheson
Jan 1, 1994·The Prostate·R SanttiJ A McLachlan
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K P Dieckmann
May 1, 1994·Current Opinion in Oncology·R T Oliver
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·F S vom SaalW V Welshons
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P J DonovanJ L Resnick
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L H LooijengaJ W Oosterhuis

❮ Previous
Next ❯

Citations

Apr 17, 2008·Cancer Causes & Control : CCC·Jonine D FigueroaKatherine A McGlynn
May 4, 2002·Molecular and Cellular Endocrinology·C R Harlow, Stephen G Hillier
Feb 18, 2003·Journal of Midwifery & Women's Health·Barbara Hammes, Cynthia J Laitman
May 18, 1999·Current Opinion in Oncology·R T Oliver
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M JørgensenH Leffers
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
Jul 11, 2001·Environmental Health Perspectives·D AxelrodL A Jones
Jul 19, 2011·Expert Review of Endocrinology & Metabolism·Jason L NellesGail S Prins
Jul 5, 2001·Environmental Research·A M SweeneyM A Smithci
Oct 8, 2005·Environmental Research·Parvathi K Basrur
Apr 4, 2007·International Journal of Occupational Medicine and Environmental Health·Hermann C RoemerKlaus Golka
Sep 5, 2013·Molecular Endocrinology·Wendy N JeffersonCarmen J Williams
Oct 28, 2015·Oncotarget·Erika Di ZazzoAntimo Migliaccio
Jul 3, 1998·Journal of Women's Health·J Adams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.