PMID: 11336416May 5, 2001Paper

Are follow-up throat cultures necessary when rapid antigen detection tests are negative for group A streptococci?

Clinical Pediatrics
T Mayes, Michael E Pichichero

Abstract

The frequency of obtaining false-negative Group A Streptococcal (GAS) rapid antigen detection (RAD) tests utilizing currently available kits in a private practice setting and the cost effectiveness of requiring follow-up throat cultures were studied. Laboratory records of the Elmwood Pediatric Group (EPG), Rochester, NY, were retrospectively reviewed to identify all patients with pharyngeal RAD tests for GAS performed from January 1996 through May 1999. From January 1996 through October 1997 (study period 1), EPG physicians used either a RAD test or a throat culture to identify GAS; from November 1997 through May 1999 (study period 2), RAD tests were used as the primary test on all patients. Rapid antigen detection test negative results were confirmed with culture. During the 3-year study 11,427 RAD tests were performed. 8,385 (73.4%) were negative and 3,042 (26.6%) were positive. In study period 1, 3,547 (73.2%) were negative and 1,299 (26.8%) were positive; in study period 2 4,837 (73.5%) were negative and 1,743 (26.5%) were positive. Of the 8,385 negative tests, 8,234 (98.2%) were followed up with throat cultures. Of these, 200 (2.4%) were identified to have been negative RAD tests that were throat culture positive (132 [3.8...Continue Reading

References

Jan 19, 1994·JAMA : the Journal of the American Medical Association·B SchwartzH Lipman
Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A L BisnoR H Schwartz
Jul 13, 1999·Archives of Pediatrics & Adolescent Medicine·J Tsevat, U R Kotagal

❮ Previous
Next ❯

Citations

May 15, 2004·Current Infectious Disease Reports·Howard M. Corneli
Jul 20, 2004·Clinical Microbiology Reviews·Michael A Gerber, Stanford T Shulman
Jun 12, 2013·Indian Journal of Pediatrics·Oznur KüçükAyça Vitrinel
Aug 13, 2014·European Journal of Pediatrics·Daan Van BrusselenPatrick Van de Voorde
Dec 3, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J CohenR Cohen
Feb 11, 2011·European Journal of Pediatrics·Carolina Giraldez-GarciaAntonio Sarria-Santamera
Sep 17, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·R Piñeiro PérezM J Cilleruelo Ortega
Oct 13, 2009·Clinics in Sports Medicine·Osric S King
Jun 10, 2008·International Journal of Pediatric Otorhinolaryngology·Aysu Duyan CamurdanUfuk Beyazova
Jul 27, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·N BuchbinderP Le Roux
Jun 1, 2005·Pediatric Clinics of North America·Michael A Gerber
Aug 19, 2006·Brazilian Journal of Otorhinolaryngology·Bernardo Cunha Araujo FilhoFlávio Akira Sakae
Apr 10, 2007·Clinical Pediatrics·Ayesha MirzaMobeen H Rathore
Oct 5, 2001·Clinical Pediatrics·P R Joseph
Jul 5, 2016·The Cochrane Database of Systematic Reviews·Jérémie F CohenMartin Chalumeau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.