Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?

Oncogene
Amélie FaubertGuy Sauvageau

Abstract

Stem cells have acquired a golden glow in the past few years as they represent possible tools for reversing the damage wreak on organs. These cells are found not only in major regenerative tissues, such as the epithelia, blood and testes, but also in 'static tissues', such as the nervous system and liver, where they play a central role in tissue growth and maintenance. The mechanism by which stem cells maintain populations of highly differentiated, short-lived cells seems to involve a critical balance between alternate fates: daughter cells either maintain stem cell identity or initiate differentiation. Recent studies in lower organisms have unveiled the regulatory mechanisms of asymmetric stem cell divisions. In these models, the surrounding environment likely provides key instructive signals for the cells to choose one fate over another. Our understanding now extends to the intrinsic mechanisms of cell polarity that influence asymmetrical stem cell divisions. This article focuses on the genetic determinants of asymmetric stem cell divisions in lower organisms as a model for studying the process of self-renewal of mammalian hematopoietic stem cells.

References

Nov 1, 1979·Journal of Ultrastructure Research·R W HardyM Garavito
Nov 1, 1984·Clinical Cardiology·H SchneidermanM Goldin
Nov 1, 1982·Journal of Clinical Pathology·F CalleaV J Desmet
Jun 1, 1994·The Journal of Cell Biology·S KondoN Hirokawa
Jan 1, 1995·Parasite Immunology·M Barral-NettoS G Reed
Dec 1, 1993·Leukemia & Lymphoma·J DelabieC De Wolf-Peeters
Jan 15, 1998·Cell·D A Sinclair, L Guarente
May 8, 1998·Nature·Y N Jan, L Y Jan
Jun 24, 1998·Genes & Development·I Greenwald
Sep 22, 1998·The Journal of Experimental Medicine·T H BrummendorfP M Lansdorp
Dec 16, 1998·Genes & Development·N Hawkins, G Garriga
Mar 18, 1999·Nature Genetics·J T WigleG Oliver
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·J M VerdiH D Lipshitz
Dec 28, 1999·Annual Review of Cell and Developmental Biology·J Chant
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N E Baker
Feb 7, 2001·Current Biology : CB·F Schweisguth

❮ Previous
Next ❯

Citations

Jan 31, 2008·Cells, Tissues, Organs·Michael A Rieger, Timm Schroeder
Nov 23, 2005·Cell Proliferation·I C Mackenzie
Apr 29, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ian C Mackenzie
Mar 17, 2012·Blood·Jonas Larsson
Feb 11, 2021·The FEBS Journal·Barry J Thompson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Critical Reviews in Oncology/hematology
Stewart Sell
Current Opinion in Genetics & Development
Peter J Donovan, Maria P de Miguel
© 2021 Meta ULC. All rights reserved