Are ghrelin and leptin involved in food intake and body mass index in maintenance hemodialysis?

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Denise MafraDenis Fouque

Abstract

Both leptin and ghrelin (in the forms of acyl ghrelin and des-acyl ghrelin) are involved in food intake, and appear to be dysregulated in chronic kidney disease. This study describes plasma leptin, acyl, and des-acyl ghrelin concentrations in relation to protein intake and body mass index (BMI) in hemodialysis (HD) patients. This was a cross-sectional study. This study was conducted during the baseline phase of the French multicenter Influence of a High-Flux Dialyzer on Long-Term Leptin Levels Study. We studied 125 HD patients (aged 72.5+/-11.7 years; 59% males). Blood samples were collected during fasting, and before a regular HD session. Plasma ghrelin and leptin were evaluated. The protein equivalents of total nitrogen appearance and BMI were calculated. Patients demonstrated elevated serum leptin (48.0+/-49.0 ng/mL) and des-acyl ghrelin (646.6+/-489.5 pg/mL) levels, and low acyl ghrelin levels (29.8+/-58.5 pg/mL), according to normal values. Acyl ghrelin was negatively correlated with C-reactive protein (r=-0.34, P < .001). The des-acyl to acyl ghrelin ratio was negatively correlated with protein intake, as estimated by normalized Protein Nitrogen Appearance (r=-0.22, P=.01). Serum leptin exhibited its well-described positi...Continue Reading

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Citations

Jun 6, 2013·International Journal of Endocrinology·Maurice DungeyNicolette C Bishop
May 13, 2011·Kidney International·Denis FouquePhilippe Chauveau
Nov 8, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Yasar CaliskanMehmet S Sever
Aug 16, 2011·Medical Hypotheses·J F SaldanhaD Mafra
Nov 17, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Denise MafraDenis Fouque
Jul 6, 2018·Frontiers in Pediatrics·Franca M Iorember

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