Are hemostasis and thrombosis two sides of the same coin?

The Journal of Experimental Medicine
Robert W Colman

Abstract

Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been considered dispensable for normal blood clotting in vivo because hereditary deficiencies in FXII are not associated with spontaneous or excessive bleeding. However, new studies show that mice lacking FXII are protected against arterial thrombosis (obstructive clot formation) and stroke. Thus, FXII could be a unique drug target that could be blocked to prevent thrombosis without the side effect of increased bleeding.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B Osterud, S I Rapaport
Sep 2, 1991·Science·D Gailani, G J Broze
Dec 1, 1973·The Journal of Experimental Medicine·C G CochraneK D Wuepper
May 1, 1972·The American Journal of Medicine·R W ColmanJ D Minna
Oct 1, 1970·Annals of Internal Medicine·J W MasonR W Colman
Feb 12, 1980·Biochemical and Biophysical Research Communications·G MillerA P Kaplan
May 1, 1993·Circulation Research·J KappelmayerR W Colman
Sep 18, 1964·Science·E W DAVIE, O D RATNOFF
May 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel Mackman
Jul 13, 2005·The Journal of Experimental Medicine·Thomas RennéBernhard Nieswandt
Aug 16, 2005·Journal of the American College of Cardiology·Takashi HattoriL Henry Edmunds
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephanie A SmithJames H Morrissey

❮ Previous
Next ❯

Citations

Sep 13, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mirko PhamChristoph Kleinschnitz
Dec 17, 2009·Hematology·Paula H B Bolton-Maggs
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Donna L PedicordYuval Blat
May 1, 2010·Current Cardiology Reports·Becky WoodruffRichard C Becker
Feb 24, 2015·Journal of Intensive Care·Takashi Ito
Jul 9, 2013·Clinics in Plastic Surgery·Alan Gold
Nov 28, 2006·The Annals of Thoracic Surgery·L Henry Edmunds, Robert W Colman
Aug 29, 2007·Journal of Thrombosis and Haemostasis : JTH·J W P Govers-RiemslagH ten Cate
Apr 18, 2016·Journal of the American Academy of Dermatology·Yunyoung ChangTania Phillips
Jun 19, 2016·Journal of Proteomics·Aline Guimarães SantanaTatiana de Arruda Campos Brasil de Souza
Apr 5, 2017·Cerebrovascular Diseases Extra·Tomohide AdachiUNKNOWN Saiseikai Stroke Research Group
Sep 10, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B C PrezotoR R Campos
Jul 4, 2007·Expert Review of Cardiovascular Therapy·Thomas Renné, David Gailani
Apr 23, 2010·British Journal of Cancer·S Noble, J Pasi
Oct 6, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·David Gailani, Thomas Renné
Dec 5, 2019·European Journal of Clinical Investigation·Candela Diaz-CañestroGiovanni G Camici
Aug 26, 2014·Biological Chemistry·Bruno R SaluMaria Luiza Vilela Oliva
Nov 17, 2016·International Journal of Hematology·Lisha LinJinhua Zhao
Jul 8, 2020·Journal of Clinical Medicine·Bastiaan ZwartRobert F Storey
Jun 18, 2014·Journal of Biomaterials Applications·Terry C MajorRobert H Bartlett
Mar 22, 2019·Scientific Reports·Aatira VijayBhuvnesh Kumar
Mar 1, 2017·Drug Delivery and Translational Research·Sarena D Horava, Nicholas A Peppas
Sep 18, 2020·European Journal of Medicinal Chemistry·Huifang SunJinhua Zhao
Mar 2, 2018·Thrombosis Research·Richard G JungBenjamin Hibbert
Jun 29, 2007·European Journal of Pharmacology·William A SchumacherMartin L Ogletree

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.