Are Hypometric Anticipatory Postural Adjustments Contributing to Freezing of Gait in Parkinson's Disease?

Frontiers in Aging Neuroscience
Christian SchlenstedtF B Horak

Abstract

Introduction: This study aims at investigating whether impaired anticipatory postural adjustments (APA) during gait initiation contribute to the occurrence of freezing of gait (FOG) or whether altered APAs compensate for FOG in Parkinson's disease (PD). Methods: Gait initiation after 30 s quiet stance was analyzed without and with a cognitive dual task (DT) in 33 PD subjects with FOG (PD+FOG), 30 PD subjects without FOG (PD-FOG), and 32 healthy controls (HC). APAs were characterized with inertial sensors and muscle activity of the tensor fasciae latae (TFL), gastrocnemius, and tibialis anterior was captured with electromyography recordings. Nine trials (of 190) were associated with start hesitation/FOG and analyzed separately. Results: PD+FOG and PD-FOG did not differ in disease duration, disease severity, age, or gender. PD+FOG had significantly smaller medio-lateral (ML) and anterio-posterior APAs compared to PD-FOG (DT, p < 0.05). PD+FOG had more co-contraction of left and right TFL during APAs compared to PD-FOG (p < 0.01). Within the PD+FOG, the ML size of APA (DT) was positively correlated with the severity of FOG history (NFOG-Q), with larger APAs associated with worse FOG (rho = 0.477, p = 0.025). ML APAs were larger du...Continue Reading

References

Mar 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A Burleigh-JacobsJ A Obeso
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Apr 14, 1999·Gait & Posture·S E HallidayF Prince
May 7, 1999·Journal of Geriatric Psychiatry and Neurology·R CamicioliJ G Nutt
Jun 26, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J D SchaafsmaN Giladi
Aug 10, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Bastiaan R BloemNir Giladi
Jun 20, 2006·Journal of the Neurological Sciences·Nir Giladi, Jeffrey M Hausdorff
Aug 12, 2006·Neuroscience Letters·Laura RocchiFay B Horak
Jul 22, 2008·Behavioural Neurology·S RahmanM Jahanshahi
Aug 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Nir Giladi, Alice Nieuwboer
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Dec 9, 2008·Experimental Neurology·Jesse V JacobsFay B Horak
May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Mark D LattVictor S C Fung
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ManciniF B Horak
May 13, 2010·Journal of Rehabilitation Medicine·Franco FranchignoniAndrea Giordano
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Joke SpildoorenAlice Nieuwboer
Apr 29, 2011·Journal of Neurophysiology·Mark W RogersColum D MacKinnon
Jun 7, 2011·Parkinsonism & Related Disorders·Martina ManciniLorenzo Chiari
Jul 23, 2011·Lancet Neurology·John G NuttAlice Nieuwboer
Nov 2, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah VercruysseElke Heremans
Jan 19, 2013·Journal of Neural Transmission·Elke HeremansS Vercruysse
Aug 9, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Bernadette SchoneburgJohn G Nutt
Jan 11, 2014·Parkinsonism & Related Disorders·Céline TardArnaud Delval
Feb 11, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Arnaud DelvalLuc Defebvre
Jun 23, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Carolin CurtzeFay B Horak
Jul 5, 2015·Gait & Posture·Ryan P DuncanGammon M Earhart
Jan 15, 2016·Parkinsonism & Related Disorders·Christian SchlenstedtGünther Deuschl
Mar 4, 2017·Archives of Physical Medicine and Rehabilitation·Christian SchlenstedtDaniel Peterson
Mar 7, 2017·Frontiers in Human Neuroscience·Rajal G CohenFay B Horak

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Citations

Aug 3, 2018·ELife·Andrea Cristina de Lima-PardiniErich Talamoni Fonoff
Mar 26, 2019·JAMA Neurology·Jorik NonnekesBastiaan R Bloem
Oct 9, 2019·Journal of Parkinson's Disease·Sommer L Amundsen HuffmasterColum D MacKinnon
Feb 6, 2020·The Journal of Physiology·Jumes Leopoldino Oliveira LiraCarla Silva-Batista
Sep 12, 2019·Frontiers in Neurology·Erich Talamoni FonoffClement Hamani
Apr 7, 2020·Neurorehabilitation and Neural Repair·Laurie A KingFay B Horak
Mar 27, 2020·Frontiers in Bioengineering and Biotechnology·Chiara PalmisanoIoannis U Isaias
Nov 16, 2018·Frontiers in Neurology·Karolina KrzysztońJan Kochanowski
Sep 11, 2019·Brain : a Journal of Neurology·Nicoló G PozziIoannis U Isaias
Jun 17, 2020·Somatosensory & Motor Research·Koichi HiraokaYasushi Sawaguchi
Oct 14, 2020·Neurorehabilitation and Neural Repair·Bruno Braz GarciaHougelle Simplício
Nov 25, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Xiaohui TangXijin Wang
Mar 23, 2021·Journal of Parkinson's Disease·Bauke W DijkstraAlice Nieuwboer
Aug 11, 2020·Journal of Parkinson's Disease·Joyce B WeersinkBauke M de Jong

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