PMID: 8981080Oct 1, 1996Paper

Are imidazoline receptors involved in sympathetic neurotransmission in rat vas deferens?

General Pharmacology
M C Avellar, R P Markus

Abstract

1. An involvement of imidazoline receptors in the modulation of neurotransmitter release was investigated in the prostatic portion of the rat vas deferens stimulated transmurally at 0.2 Hz or by single pulses. 2. Idaxozan and yohimbine induced a concentration-dependent potentiation of the contractile response to 0.2-Hz transmural stimulation in the epididymal and prostatic portion of the vas. 3. After reserpine treatment, idazoxan, but not yohimbine, still potentiated the contractile response, suggesting a possible involvement of imidazoline receptors. 4. Clonidine and rilmenidine, agonists with different affinities to alpha 2-adrenoceptors and imidazoline receptors, inhibited with the same potency the contractile responses to a single pulse transmural stimulation. 5. Yohimbine (a selective alpha 2-adrenoceptor antagonist) antagonized the inhibitory concentration effect curve to rilmenidine in a competitive manner. pA2 values for idaxozan (an antagonist to alpha 2-adrenoceptors and imidazoline receptors) were not different when noradrenaline or rilmenidine were used as agonists. Phenoxybenzamine blocked the effect of both agonists. 6. Thus, the potency relationship of agonists, as well as the effect of the antagonists, did not ...Continue Reading

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Citations

Nov 1, 2002·European Journal of Pharmacology·Gaëll Mayer, Peter V Taberner
Sep 25, 2002·Life Sciences·Edwin O OkpalaugoAron Jurkiewicz
Jan 15, 1999·General Pharmacology·G J Molderings, M Göthert
Jul 30, 2002·British Journal of Pharmacology·Scott SloughPeter V Taberner
May 2, 2003·The Journal of Pharmacy and Pharmacology·Wilson C SantosLúcia Garcez-do-Carmo

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