Abstract
1. An involvement of imidazoline receptors in the modulation of neurotransmitter release was investigated in the prostatic portion of the rat vas deferens stimulated transmurally at 0.2 Hz or by single pulses. 2. Idaxozan and yohimbine induced a concentration-dependent potentiation of the contractile response to 0.2-Hz transmural stimulation in the epididymal and prostatic portion of the vas. 3. After reserpine treatment, idazoxan, but not yohimbine, still potentiated the contractile response, suggesting a possible involvement of imidazoline receptors. 4. Clonidine and rilmenidine, agonists with different affinities to alpha 2-adrenoceptors and imidazoline receptors, inhibited with the same potency the contractile responses to a single pulse transmural stimulation. 5. Yohimbine (a selective alpha 2-adrenoceptor antagonist) antagonized the inhibitory concentration effect curve to rilmenidine in a competitive manner. pA2 values for idaxozan (an antagonist to alpha 2-adrenoceptors and imidazoline receptors) were not different when noradrenaline or rilmenidine were used as agonists. Phenoxybenzamine blocked the effect of both agonists. 6. Thus, the potency relationship of agonists, as well as the effect of the antagonists, did not ...Continue Reading
References
Jun 1, 1977·The Journal of Pharmacy and Pharmacology·R R RuffoloP N Patil
Aug 20, 1979·Life Sciences·R J TallaridaM W Adler
Jan 25, 1991·European Journal of Pharmacology·V Lachaud-PettitiA Parini
Mar 26, 1991·European Journal of Pharmacology·R E GomezD J Reis
Dec 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·G J MolderingsM Göthert
Mar 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·M Göthert, G J Molderings
Jan 11, 1991·Pharmacology·M A OriowoR R Ruffolo
Sep 1, 1991·British Journal of Pharmacology·M PortilloJ L Montastruc
Dec 17, 1991·European Journal of Pharmacology·E TibiriçaP Bousquet
Aug 1, 1991·Journal of Autonomic Pharmacology·C A HamiltonJ L Reid
Jul 1, 1990·Journal of Neurochemistry·J E Wikberg, S Uhlén
Apr 1, 1990·British Journal of Pharmacology·C M BrownA T Kilpatrick
Oct 1, 1990·British Journal of Pharmacology·S Connaughton, J R Docherty
Apr 25, 1989·European Journal of Pharmacology·G BriccaP Bousquet
Jan 1, 1989·Life Sciences·J LehmannP Vitou
Jan 14, 1986·Biochemical and Biophysical Research Communications·S Diamant, D Atlas
Mar 24, 1986·Life Sciences·M P MeeleyD J Reis
Feb 9, 1988·European Journal of Pharmacology·C A HamiltonM A Yakubu
Mar 1, 1983·British Journal of Pharmacology·J C DoxeyC F Smith
Dec 24, 1981·Nature·A G BlakeleyN C Scott
Jun 1, 1983·British Journal of Pharmacology·D A BrownN C Scott
Nov 25, 1983·European Journal of Pharmacology·E S ViziG Folly
Aug 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·H Fuder, P Schwarz
Jan 1, 1990·Neurochemistry International·G VauquelinG Ebinger
Citations
Nov 1, 2002·European Journal of Pharmacology·Gaëll Mayer, Peter V Taberner
Sep 25, 2002·Life Sciences·Edwin O OkpalaugoAron Jurkiewicz
Jan 15, 1999·General Pharmacology·G J Molderings, M Göthert
Jul 30, 2002·British Journal of Pharmacology·Scott SloughPeter V Taberner
May 2, 2003·The Journal of Pharmacy and Pharmacology·Wilson C SantosLúcia Garcez-do-Carmo