Are immunotherapies for Huntington's disease a realistic option?

Molecular Psychiatry
Hélèna L DenisF Cicchetti

Abstract

There is compelling evidence that the pathophysiology of many neurodegenerative diseases includes dysregulation of the immune system, with some elements that precede disease onset. However, if these alterations are prominent, why have clinical trials targeting this system failed to translate into long-lasting meaningful benefits for patients? This review focuses on Huntington's disease, a genetic disorder marked by notable cerebral and peripheral inflammation. We summarize ongoing and completed clinical trials that have involved pharmacological approaches to inhibit various components of the immune system and their pre-clinical correlates. We then discuss new putative treatment strategies using more targeted immunotherapies such as vaccination and intrabodies and how these may offer new hope in the treatment of Huntington's disease as well as other neurodegenerative diseases.

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Citations

Jun 12, 2019·Expert Review of Neurotherapeutics·Hassaan Bashir
Aug 22, 2018·Molecular Psychiatry·Marie RieuxFrancesca Cicchetti
Apr 18, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Congcong ZhangAndrea L J Marschall
Feb 8, 2020·Current Neuropharmacology·Shareen Singh, Thakur Gurjeet Singh
Jul 16, 2019·Life Sciences·Priscila Aparecida Costa ValadãoAline Silva de Miranda

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Methods Mentioned

BETA
transgenic
antisense

Clinical Trials Mentioned

NCT00146211
NCT00277355
NCT00029874
NCT01357681
NCT01502046
NCT02215616
NCT02481674
NCT00916201

Software Mentioned

DOMINO
Vaccinex
TEVA

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