Are iodinated contrast agents detrimental in acute cerebral ischemia? An experimental study in rats

Radiology
A DoerflerM Forsting

Abstract

To study the effects of iothalamate sodium and two dosages of iopromide in acute cerebral ischemia on infarction volume, neurologic performance, and mortality in a rat model of middle cerebral artery occlusion. Sixty-four rats underwent endovascular occlusion of the middle cerebral artery. Four hours later, 16 animals received iothalamate sodium (588 mg iodine per kilogram); 16, iopromide as a single bolus (518 mg iodine per kilogram); and 16, iopromide as a double bolus (1,036 mg iodine per kilogram). Sixteen animals received equivolumetric saline (control group). Neurologic score and body weight were recorded every 8 hours. Twenty-four hours after occlusion, all animals were killed; brains were stained to assess the infarction size. Single and double doses of iopromide did not affect infarction volume or neurologic performance. Iothalamate caused an increase in infarction volume and worsening of the neurologic score (p < .05). Mortality rate was 25% in the iothalamate group, 12% in the control group, and 6% in the iopromide groups. Bolus injection of the nonionic iopromide does not statistically significantly affect infarction volume or cerebral ischemia symptoms. Nonionic rather than ionic contrast agents should be preferred...Continue Reading

Citations

Sep 6, 2008·Stroke; a Journal of Cerebral Circulation·Pooja KhatriUNKNOWN IMS I and II Investigators
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Erica C Sá de Camargo, Walter J Koroshetz
Aug 5, 2000·Radiology·R von Kummer
Jun 29, 2007·Cerebrovascular Diseases·Martin KöhrmannPeter D Schellinger
Jan 6, 2001·Topics in Magnetic Resonance Imaging : TMRI·M H Lev, S J Nichols
Jun 7, 2011·Neuroimaging Clinics of North America·Angelos A KonstasMichael H Lev
Jul 9, 2010·Radiologic Clinics of North America·Josser E Delgado AlmandozMichael H Lev
Dec 20, 2005·Neuroimaging Clinics of North America·Sanjay K Shetty, Michael H Lev
Dec 15, 2015·Radiologic Clinics of North America·Suyash MohanBryan Pukenas
Jun 24, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Seongmin HaKyu Tae Lee
Mar 4, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Ryan P RadeckiRosa C Banuelos
Jan 6, 2006·Seminars in Ultrasound, CT, and MR·Javier M Romero
Sep 17, 2008·Handbook of Clinical Neurology·Joachim RötherMichael H Lev
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·R von Kummer, S Patel
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Mustapha A EzzeddineWalter J Koroshetz
Oct 3, 2009·Stroke; a Journal of Cerebral Circulation·Richard E LatchawUNKNOWN American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, and the Interdisciplinary C
Jul 9, 2011·Stroke; a Journal of Cerebral Circulation·Niall J J MacdougallKeith W Muir
Feb 20, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Midori KusamaKenji Miyagi
Dec 3, 2016·Journal of Neurointerventional Surgery·Humberto MoralesThomas Tomsick

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