Are lactoferrin receptors in Gram-negative bacteria viable vaccine targets?

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Clement ChanAnthony B Schryvers

Abstract

A number of important Gram-negative pathogens that reside exclusively in the upper respiratory or genitourinary tract of their mammalian host rely on surface receptors that specifically bind host transferrin and lactoferrin as a source of iron for growth. The transferrin receptors have been targeted for vaccine development due to their critical role in acquiring iron during invasive infection and for survival on the mucosal surface. In this study, we focus on the lactoferrin receptors, determining their prevalence in pathogenic bacteria and comparing their prevalence in commensal Neisseria to other surface antigens targeted for vaccines; addressing the issue of a reservoir for vaccine escape and impact of vaccination on the microbiome. Since the selective release of the surface lipoprotein lactoferrin binding protein B by the NalP protease in Neisseria meningitidis argues against its utility as a vaccine target, we evaluated the release of outer membrane vesicles, and transferrin and lactoferrin binding in N. meningitidis and Moraxella catarrhalis. The results indicate that the presence of NalP reduces the binding of transferrin and lactoferrin by cells and native outer membrane vesicles, suggesting that NalP may impact all lip...Continue Reading

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Citations

May 20, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hans J VogelPiera Valenti

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Methods Mentioned

BETA
PCR
affinity capture

Software Mentioned

PyMOL
BLAST
HIT
Model
CD
Scikit Learn
Scikit
European Molecular Biology Open Source Suite ( EMBOSS )
SPAdes
BLASTN

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