Are long-term bisphosphonate users a reality? Dose years for current bisphosphonate users assessed using the danish national prescription database.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
B Abrahamsen

Abstract

The prevalence of long-term bisphosphonate use may be low due to low refill compliance and gaps in treatment. An analysis of the prescription history of 58,674 bisphosphonate users in Denmark found that only 2.8 % had received ten dose years of treatment or above. This study aims to describe the demographics of present bisphosphonate (BP) users, to determine the prevalence of long-term BP use, and to establish if long-term use (a 10-year history of osteoporosis treatment) translated to ten dose years of bisphosphonate prescriptions filled, given the propensity for treatment gaps and low refill compliance with bisphosphonates. The study population was all persons aged 35 and above, who had filled at least one prescription for an oral bisphosphonate in the year 2008. Past use of osteoporosis medications (bisphosphonates, raloxifene, strontium ranelate, or PTH analogs) for the period January 1, 1995 to December 31, 2007 was retrieved from the Danish National Prescription Database for descriptive analysis. Of the 58,674 BP users, 46 % were above the age of 75, and 13 % were men. Though 5.9 % had at least a 10-year history of treatment, only half (2.8 %) had received more than ten dose years of a BP. For any osteoporosis drug, 3.0 %...Continue Reading

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Citations

Sep 12, 2014·Calcified Tissue International·Angela G JubyMarilyn Cree
Feb 5, 2014·Expert Opinion on Drug Discovery·Peter SchwarzBo Abrahamsen
Feb 11, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bo AbrahamsenCyrus Cooper
Oct 24, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Dima L Diab, Nelson B Watts

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