PMID: 7019319Aug 1, 1981Paper

Are many women immunized against rubella unnecessarily?

The Journal of Hygiene
P P MortimerA Hutchinson

Abstract

Radial haemolysis (RH) was used to test sera for immunity to rubella from 1317 patients attending a general practice. One hundred and forty-one (10.7%) were treated as susceptible and offered an attenuated virus vaccine (RA 27/3). Pre-immunization sera from 43% of these patients were reactive at low levels in RH (less than 15 international units rubella antibody per ml). Pre- (S1) and post- (S2) immunization sera from 66 vaccinees were studied in detail. Antibody was detected by RH, haemagglutination inhibition (HI) and enzyme-linked immunosorbent assay (ELISA), and the specific IgM response was measured by a solid-phase M-antibody capture radioimmunoassay (MACRIA). The vaccine-induced IgM response was only detected if the S1 serum was non-reactive by all tests for rubella antibody. It was weaker than that seen following wild virus infection. It could be detected reliably for six weeks, and in most cases for nine weeks, after immunization. In contrast, patients with S1 specimens reactive by RH, HI or ELISA never showed an IgM response in the S2 specimen despite "significant' antibody rises often being present. It was considered that an IgM response to RA 27/3 was the best indicator of pre-immunization susceptibility to rubella....Continue Reading

Citations

Nov 1, 1986·Journal of Virological Methods·K BellamyP S Gardner
Feb 1, 1983·The Journal of Hygiene·P P Mortimer, R S Tedder
Feb 1, 1984·The Journal of Hygiene·H G Murray
Jun 1, 1984·The Journal of Hygiene·P P MortimerJ Haslehurst
Apr 1, 1986·The Journal of Hygiene·D J NokesM J Anderson
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Aug 1, 1991·Epidemiology and Infection·J E Cradock-Watson
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May 1, 1982·British Medical Journal·J E Banatvala
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Dec 8, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Daniela HuzlyMarcus Panning
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Apr 1, 1982·The Journal of Hygiene·J R Pattison
Feb 4, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·O PiconeC Vauloup-Fellous
Jan 1, 1983·Journal of Clinical Microbiology·P W Neumann, J M Weber

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