Are medical comorbid conditions of bipolar disorder due to immune dysfunction?

Acta Psychiatrica Scandinavica
Joshua D Rosenblat, Roger S McIntyre

Abstract

Epidemiological data have shown a clear association between bipolar disorder (BD) and medical comorbidities. The aim of this article was to assess the evidence of immune dysfunction as a key mediator of this observed association. For this narrative clinical overview, the MEDLINE/PubMed, EMBASE, Google Scholar, and ClinicalTrials.gov databases were searched for relevant articles. Bipolar disorder has been shown to have an increased prevalence in patients with autoimmune disorders, cardiovascular disease, and metabolic dysfunction. Further, an elevation in proinflammatory cytokines in BD has been repeatedly demonstrated. Several mechanisms have been proposed to explain the effect of immune dysfunction on mood and cognition. Anti-inflammatory agents including TNF-α inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), minocycline and omega-3 polyunsaturated fatty acids (O3PUFA) are being investigated for their use as novel treatment of BD in patients with immune dysfunction. Immune dysfunction appears to be an important mediator of the association observed between BD and medical comorbidities. It therefore serves as a potential novel target for treatment of BD. Further, the observed bidirectional interaction merits screening...Continue Reading

References

May 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·B E Murphy
Sep 1, 1991·The American Journal of Clinical Nutrition·A P Simopoulos
Jul 1, 1980·Comprehensive Psychiatry·S L Lilliker
Apr 1, 1996·The American Journal of Psychiatry·J LevineJ Zimmerman
Jun 17, 1998·Psychological Medicine·R H McAllister-WilliamsA H Young
May 8, 1999·Archives of General Psychiatry·A L StollL B Marangell
May 16, 2001·Archives of General Psychiatry·A ReichenbergT Pollmächer
Jul 24, 2001·Clinical Cornerstone·G A Green
Sep 26, 2001·Archives of General Psychiatry·U OsbyP Sparén
Apr 18, 2002·Biological Psychiatry·Ralph W KupkaHemmo A Drexhage
Jun 14, 2002·Journal of Affective Disorders·F AngstJ Angst
Jul 30, 2002·Progress in Brain Research·Victoria ArangoJ John Mann
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·T S ChurchS N Blair
Apr 15, 2004·Journal of Neuroimmunology·Hsing-Cheng LiuSy-Jye Leu
Oct 9, 2004·Pharmacopsychiatry·U M H KlumpersA J M Loonen
Dec 8, 2004·Brain, Behavior, and Immunity·Charles L RaisonAndrew H Miller
May 12, 2005·Neuroscience and Biobehavioral Reviews·Adrian J DunnRenaud de Beaurepaire
Jun 10, 2005·Brain, Behavior, and Immunity·C E WrightA Steptoe
Aug 4, 2005·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Roger S McIntyreSidney H Kennedy
May 25, 2006·Current Opinion in Psychiatry·Wayne S Fenton, Ellen S Stover
Oct 31, 2006·Schizophrenia Research·Christoph U CorrellPeter Manu
Apr 17, 2007·Journal of Affective Disorders·Yong-Ku KimSun-Hwa Park
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Dec 29, 2007·The Journal of Clinical Psychiatry·Gregor E BergerPatrick D McGorry
Oct 28, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Philip C Calder
Mar 3, 2009·Journal of Affective Disorders·Elisa BrietzkeFlávio Kapczinski
Jan 1, 2008·Primary Care Companion to the Journal of Clinical Psychiatry·Mohammad Jafferany
May 2, 2009·Brain, Behavior, and Immunity·Elisa BrietzkeFlávio Kapczinski
May 30, 2009·Arthritis and Rheumatism·Elizabeth A BachenLindsey A Criswell
Aug 20, 2009·Bipolar Disorders·Cynthia CalkinMartin Alda
Jan 26, 2010·Cellular Signalling·Keigan M Park, William J Bowers
Jun 15, 2010·Journal of Affective Disorders·Roger S McIntyreValerie H Taylor
Sep 28, 2010·Bipolar Disorders·William W EatonPreben Bo Mortensen
Dec 9, 2010·Journal of Psychiatry & Neuroscience : JPN·Johan SöderlundGöran Engberg
Dec 18, 2010·Neuromolecular Medicine·Joanna K SoczynskaRoger S McIntyre

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Citations

Feb 16, 2016·The Psychiatric Clinics of North America·Joshua D Rosenblat, Roger S McIntyre
Oct 7, 2015·Brain, Behavior, and Immunity·Frieder HaenischSabine Bahn
Jul 21, 2015·Acta Psychiatrica Scandinavica·M Leboyer
Aug 9, 2015·Journal of Affective Disorders·Gabriela D ColpoAndré F Carvalho
Feb 20, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hui Hua ChangPo See Chen
May 18, 2016·Journal of Affective Disorders·Behdin NowrouziVincenzo De Luca
May 4, 2016·Psychoneuroendocrinology·Rugül Köse ÇinarYasemin Görgülü
Oct 1, 2016·Brain and Behavior·Ruth Ann MarrieLarry Svenson
Jul 9, 2016·International Journal of Bipolar Disorders·Ellen F CharlesBerit Kerner
Oct 30, 2016·Journal of Affective Disorders·Massimiliano BuoliA Carlo Altamura
Oct 30, 2016·BMC Medicine·Marion LeboyerLaurent Groc
Jan 21, 2018·International Journal of Bipolar Disorders·Wahid BoukouaciRyad Tamouza
Nov 10, 2017·Current Neuropharmacology·Ya-Qun ZhouYu-Ke Tian
Dec 13, 2017·Journal of Clinical Psychopharmacology·John J Mooney, Roscoe O Brady
Feb 14, 2019·Psychopharmacology·Joshua D Rosenblat
Jun 6, 2020·BJPsych Open·Brett D M JonesM Ishrat Husain
May 20, 2017·Psychiatry and Clinical Neurosciences·Shang-Ying TsaiWen-Cheng Wu
Sep 24, 2020·Case Reports in Psychiatry·Selima ChebliFethi Nacef
Jul 24, 2018·Frontiers in Pharmacology·Marco A De BastianiFabio Klamt
May 8, 2018·Current Psychiatry Reports·Aktriti SinhaIhsan M Salloum
Nov 4, 2017·Epidemiology and Psychiatric Sciences·R A MarrieUNKNOWN CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease
Jul 10, 2018·Inflammatory Bowel Diseases·Charles N BernsteinUNKNOWN CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease
Jul 10, 2019·The Australian and New Zealand Journal of Psychiatry·Richard J Porter
Sep 6, 2018·Therapeutic Advances in Psychopharmacology·Tobias A Rowland, Steven Marwaha
Mar 16, 2021·Frontiers in Cellular Neuroscience·Heather K HughesPaul Ashwood
Jul 18, 2017·Neuroscience and Biobehavioral Reviews·Mehdi GhasemiAhmad Salehi
Jun 25, 2020·Journal of Neuroimmunology·Aline Silva de MirandaAntônio Lúcio Teixeira
Jul 2, 2021·Brain and Behavior·Anthony G Pacholko, Lane K Bekar

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