Are MRI-detected erosions specific for RA? A large explorative cross-sectional study

Annals of the Rheumatic Diseases
Debbie M BoetersAnnette H M van der Helm-van Mil

Abstract

MRI is recommended in the diagnostic process of rheumatoid arthritis (RA) to detect joint damage early. MRI-detected erosions are also present in symptom-free controls, especially at older age. It is unclear if RA-specific MRI-detected erosions can be distinguished from 'physiological' erosions in symptom-free individuals. This study compared MRI-detected erosions of patients with RA with healthy controls and with other arthritides. 589 newly presenting patients with early arthritis (238 RA, 351 other arthritides) and 193 symptom-free controls underwent contrast-enhanced 1.5T MRI of unilateral metacarpophalangeal and metatarsophalangeal (MTP) joints. Total erosion score (according to the Rheumatoid Arthritis MRI Scoring System), number, severity, location of erosions and simultaneous presence of MRI-detected inflammation (synovitis and/or bone marrow oedema) were compared; participants were categorised in three age groups (<40, 40-59, ≥60). Patients with RA had statistically significant higher total erosion scores than controls but scores of individual persons largely overlapped. Grade ≥2 erosions and MTP5 erosions were specific for RA (specificity 98%-100% and 90%-98% for different age groups). MTP1 erosions were only specific...Continue Reading

References

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Jul 20, 2010·Rheumatology·Diederik P C de RooyAnnette H M van der Helm-van Mil
Feb 5, 2013·Annals of the Rheumatic Diseases·Désirée van der HeijdeBernard Combe
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Apr 16, 2014·Arthritis Research & Therapy·Lena InnalaSolveig Wållberg-Jonsson
Aug 25, 2015·Arthritis Research & Therapy·Lukas MangnusAnnette H M van der Helm-van Mil
Feb 19, 2017·Annals of the Rheumatic Diseases·Camille RoubilleBernard Combe

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Citations

Dec 7, 2018·The Journal of Rheumatology·Julie E DavisJeffrey B Driban
Aug 2, 2018·Annals of the Rheumatic Diseases·Debbie M BoetersAnnette H M van der Helm-van Mil
Dec 15, 2019·Journal of Clinical Medicine·Lena HirtlerFranz Kainberger
May 15, 2018·Expert Review of Clinical Immunology·Jiang YueLai-Shan Tam
Aug 17, 2019·The Journal of Rheumatology·Nina RennerMilena L Pachowsky

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