Are nodal metastases in ovarian cancer chemoresistant lesions? Comparative study of initial lymphadenectomy or after chemotherapy

Gynécologie, obstétrique & fertilité
F JoulieD Castaigne

Abstract

The aim of this study is to compare the rates of nodal involvement in epithelial ovarian cancer (EOC) in patients who underwent initial lymphadenectomy (before chemotherapy/group 1) and patients who underwent lymphadenectomy after chemotherapy (during interval debulking surgery/group 2 or second-look surgery/group 3). The rates of nodal involvement in 205 patients with EOC who underwent complete pelvic and paraaortic lympadenectomy were compared. One hundred and five patients underwent this surgical procedure at the end of chemotherapy (group 3) or during chemotherapy (group 2) for 28 patients (with three courses of a platinum-based regimen containing paclitaxel) and were compared to 100 patients who underwent initial lymphadenectomy (group 1). In patients with stage I and II disease the rate of nodal involvement in group 1 and 3 were similar (respectively 19% vs. 21% and 50% vs. 33% in stage I or II disease-NS). In patients with stage III disease, the rates of nodal involvement in patients treated with initial surgery, interval debulking surgery (with paclitaxel-based regimen) and second-look surgery were respectively: 53%, 58% and 48% (NS). Adding to the platinum-based regimen does not seem to improve node sterilization rates...Continue Reading

References

Mar 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·F Di ReE Di Re
Mar 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·P C WuL J Lian
Mar 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·E Burghardt, R Winter
Nov 1, 1986·American Journal of Obstetrics and Gynecology·P C WuL J Lian
Jun 1, 1994·Gynecologic Oncology·F Guidozzi, J H Ball
Jun 1, 1997·American Journal of Obstetrics and Gynecology·R E KimballN M Spirtos
Mar 10, 1998·Obstetrics and Gynecology·G MichelP Duvillard
Oct 16, 1999·American Journal of Clinical Oncology·M ShimadaN Terakawa
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L de PonchevilleG Body
Dec 19, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P MoriceD Castaigne
Aug 2, 2003·Journal of the American College of Surgeons·Philippe MoriceDamienne Castaigne

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Citations

Jul 6, 2013·Archives of Gynecology and Obstetrics·Lingling FanCongjian Xu
Nov 18, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L VerleyeUNKNOWN Gynaecological Cancer Group (GCG) of European Organisation for Research and Treatment of Cancer (EORTC)
Mar 10, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nan Song, Yunong Gao
May 10, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Romain DelangleUNKNOWN FRANCOGYN Research Group

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