PMID: 6407955Jul 1, 1983Paper

Are nuclear particles specific for non-A, non-B hepatitis?

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
R de VosV J Desmet

Abstract

This study reports the findings of an electron microscopic search for so-called non-A, non-B nuclear particles in liver biopsies from patients with mainly chronic or prolonged liver disease and from chimpanzees. In patients without hepatitis B virus or acute hepatitis A virus serological markers, non-A, non-B-like nuclear particles were seen in hepatocytes in 28 of 31 cases of presumed non-A, non-B hepatitis, but also in 11 of 12 cases of liver disease not usually attributed to hepatitis viruses. They were also seen in 22 of 24 patients with HBsAg, in 3 of 3 patients with anti-HBc and no HBsAg, in 1 of 2 patients with hepatitis A, in a case of cytomegalovirus hepatitis, and in 16 of 19 patients whose serology was not available or inconclusive. The particles were present in 1 of 8 untreated HBsAg-negative chimpanzees and in 2 of 2 HBsAg-positive chimpanzees. They appeared in 4 of 4 chimpanzees developing non-A, non-B hepatitis following exposure to various inocula. Three patterns of particle aggregates were distinguished, all of which had been shown by others in non-A, non-B hepatitis. Dense aggregates were predominant, while others have shown intermediate aggregates more often; reasons for this difference could be technical. No...Continue Reading

References

Oct 1, 1979·Journal of Ultrastructure Research·M Wassef
Oct 1, 1979·Journal of Ultrastructure Research·E PuvionM J Burglen
Jan 1, 1969·Acta Pathologica Et Microbiologica Scandinavica·H Poulsen, P Christoffersen
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·U PfeiferO Klinge
Jan 1, 1980·Journal of Medical Virology·K N TsiquayeA J Zuckerman
Jan 1, 1980·Journal of Medical Virology·K GmelinB von Ehrlich
Jan 1, 1981·Journal of Medical Virology·C A BusachiF Tremolada
Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Marciano-CabralG A Cabral
Dec 1, 1981·Human Pathology·P V Holland, H J Alter
Jan 1, 1982·Experimental Pathology·K D KunzeF Renger
Mar 1, 1981·Liver·C De Wolf-PeetersJ De Groote
Sep 1, 1981·Liver·J H Hoofnagle, S M Feinstone
Oct 1, 1981·The Journal of Pathology·K M Robinson, M A Gregory

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Citations

Jul 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valeer J Desmet
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H SpichtinL Bianchi
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A BusachiE Pisi
Jun 1, 1987·Journal of Medical Virology·T WatanabeT Shibayama
Jun 1, 1988·Acta Pathologica Japonica·G Yamada, T Tsuji

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