Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort.

BMJ Open
Andrew J SimpkinRebecca Hardy

Abstract

Our aim was to investigate the association of epigenetic age and physical capability in later life. Having a higher epigenetic than chronological age (known as age acceleration (AA)) has been found to be associated with an increased rate of mortality. Similarly, physical capability has been proposed as a marker of ageing due to its consistent associations with mortality. The MRC National Survey of Health and Development (NSHD) cohort study. We used data from 790 women from the NSHD who had DNA methylation data available. Epigenetic age was calculated using buccal cell (n=790) and matched blood tissue (n=152) from 790 female NSHD participants. We investigated the association of AA at age 53 with changes in physical capability in women from ages 53 to 60-64. Regression models of change in each measure of physical capability on AA were conducted. Secondary analysis focused on the relationship between AA and smoking, alcohol, body mass index (BMI) and socioeconomic position. Three objective measures of physical capability were used: grip strength, standing balance time and chair rise speed. Epigenetic age was lower than chronological age (mean 53.4) for both blood (50.3) and buccal cells (42.8). AA from blood was associated with a ...Continue Reading

Citations

Jan 13, 2018·GeroScience·Dustin R MasserWillard M Freeman
Sep 5, 2019·International Journal of Molecular Sciences·Chengchen LiYan V Sun
Jan 22, 2020·Clinical Epigenetics·Eliza FraszczykJana V van Vliet-Ostaptchouk
Jul 15, 2020·International Journal of Legal Medicine·Barbara Elisabeth KoopStefanie Ritz-Timme
Apr 20, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joanne RyanRobyn L Woods
Aug 21, 2019·Frontiers in Physiology·Noémie GensousPaolo Garagnani
Aug 17, 2020·Neuroscience and Biobehavioral Reviews·Natasha M WoodSarah Cohen-Woods
Mar 7, 2021·International Journal of Environmental Research and Public Health·Natalie KlempelMark A Tully
Apr 29, 2021·Journal of Epidemiology and Community Health·Anitha GeorgeJane Maddock
Sep 21, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tiina FöhrElina Sillanpää

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