PMID: 6107855Oct 16, 1980Paper

Are only alpha 2-adrenergic receptors present in bovine retina?

Nature
H BittigerN Wigger

Abstract

The retina represents a part of the central nervous system (CNS) with a well studied, geometrically defined structure and a specialized function--the processing of light signals. Neurotransmitters such as glutamate, aspartate, glycine, gamma-aminobutyric acid (GABA), dopamine and acetylcholine are considered to be involved in the neuronal activity of the retina. Receptors for acetylcholine, GABA, dopamine and benzodiazepines have also been demonstrated. Thus, the retina can be considered as a model for the study of neuronal processing in general, in which the input, light signals, can be selected and regulated in a defined way. We report here that alpha-adrenergic receptors in the bovine retina have been characterized using radioreceptor assays. 3H-phentolamine (an alpha 1- and alpha 2-antagonist), 3H-clonidine (a preferential alpha 2-agonist) and 3H-WB 4101 [(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane, an alpha 1-antagonist] were used as radioligands, and WB 4101 and prazosin (alpha 1-antagonists), tolazine (an alpha 2-antagonist), yohimbine and its stereoisomers rauwolscine (preference for alpha 2-receptors) and corynanthine (preference for alpha 1-receptors), were used as inhibitors of radioaligand binding. Only ...Continue Reading

References

Sep 3, 1976·Brain Research·B Ehinger, B Lindberg-Bauer
Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Dec 9, 1977·Brain Research·D C U'prichardS H Snyder
May 1, 1979·European Journal of Pharmacology·P Greengrass, R Bremner
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C BrandonJ Y Wu
Jun 16, 1978·Brain Research·R E HruskaH I Yamamura
Oct 1, 1976·General Pharmacology·M J Neal
Oct 8, 1976·Brain Research·S J Enna, S H Snyder
Feb 1, 1980·Neuroscience Letters·N N Osborne
Sep 1, 1977·Neuroscience Letters·W E Müller

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Citations

Feb 5, 1982·European Journal of Pharmacology·R OrtmannA Delini-Stula
Sep 10, 1984·Life Sciences·M Hadjiconstantinou, N H Neff
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·H O BorbeU Woller
Oct 1, 1984·Neuroscience·M HadjiconstantinouN H Neff
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Jul 5, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·C S SpadaD F Woodward
Jan 1, 1988·Neuroscience Research. Supplement : the Official Journal of the Japan Neuroscience Society·N N Osborne, H Ghazi
Jul 1, 1997·Journal of Pharmaceutical Sciences·C J BolJ W Mandema
Jan 1, 1984·Annals of the New York Academy of Sciences·M L Dubocovich
Nov 1, 1983·Journal of Neurochemistry·M HadjiconstantinouN H Neff
Oct 1, 1989·Medicinal Research Reviews·J C McGrathV G Wilson

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