Are ovarian cancer stem cells the target for innovative immunotherapy?

OncoTargets and Therapy
Liang WangManhua Cui

Abstract

Cancer stem cells (CSCs), a subpopulation of cancer cells with the ability of self-renewal and differentiation, are believed to be responsible for tumor generation, progression, metastasis, and relapse. Ovarian cancer, the most malignant gynecological cancer, has consistent pathology behavior with CSC model, which suggests that therapies based on ovarian cancer stem cells (OCSCs) can gain a more successful prognosis. Much evidence has proved that epigenetic mechanism played an important role in tumor formation and sustainment. Since CSCs are generally resistant to conventional therapies (chemotherapy and radiotherapy), immunotherapy is a more effective method that has been implemented in the clinic. Chimeric antigen receptor (CAR)-T cell, an adoptive cellular immunotherapy, which results in apparent elimination of tumor in both hematologic and solid cancers, could be used for ovarian cancer. This review covers the basic conception of CSCs and OCSCs, the implication of epigenetic mechanism underlying cancer evolution considering CSC model, the immunotherapies reported for ovarian cancer targeting OCSCs currently, and the relationship between immune system and hierarchy cancer organized by CSCs. Particularly, the promising prospe...Continue Reading

Citations

Feb 6, 2019·International Journal of Molecular Sciences·Rüdiger KlapdorAxel Schambach
Aug 18, 2020·OncoTargets and Therapy·Yucong LiQi Zhou
Apr 8, 2020·Frontiers in Oncology·Nastassja TerraneoJürgen Grünberg
Jul 4, 2018·International Journal of Molecular Sciences·Ángela ÁyenHouria Boulaiz
Apr 4, 2021·International Journal of Molecular Sciences·Katarzyna M TerlikowskaSławomir J Terlikowski
May 1, 2021·International Journal of Molecular Sciences·Srishti JainTracy Robson

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Methods Mentioned

BETA
glycosylation
xenograft
transfection

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