PMID: 10427867Jul 31, 1999

Are oxygen indices effective for predicting pathological intrapulmonary shunt in mechanically ventilated children?

Archives of Medical Research
I Maulen-RadovanM Márquez Aguirre

Abstract

This study was undertaken to evaluate whether oxygen indices accurately predict pathological intrapulmonary shunt (Qsp/Qt), and to evaluate the sensitivity and specificity of the FiO2-required formula to obtain a desired arterial oxygen tension (PaO2) in mechanically ventilated children. A prospective, hospital-based, comparative study was conducted on 50 mechanically ventilated children at the Intensive Care Units of the National Institute of Pediatrics (INP) in Mexico City. Blood gas data were prospectively collected from 50 critically ill, mechanically ventilated children, 50 taken before and 40 after FiO2 change. Assessment of Qsp/Qt, P(A-a)O2, PaO2/FiO2, PaO2/PAO2, and P(A-a)O2/PaO2 was carried out before and after FiO2 change. In first blood gas data, 31 patients were hypoxemic (PaO2 < 90 Torr), 10 were normal, and 9 were hyperoxemic (PaO2 > 100 Torr). Forty patients required FiO2 modifications that were carried out according to Maxwell's formula. Five children showed persistent oxygen disturbance after FiO2 changes. P(A-a)O2, PaO2/FiO2, PaO2/PAO2, and P(A-a)O2/PaO2 had sensitivities of 0.66, 0.71, 0.98, and 0.93, respectively, and specificities of 0.79, 0.91, 0.29, and 0.64, respectively, to detect pathological Qsp/Qt. A...Continue Reading

References

Jan 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I A HerrickA B Froese
Oct 1, 1988·Acta Anaesthesiologica Scandinavica·H Zetterström
Feb 1, 1986·Critical Care Medicine·J P VialeJ Motin
Aug 1, 1983·Critical Care Medicine·H D CovelliW K Tuttle
Jan 1, 1997·Critical Care Medicine·M S Gowda, R A Klocke

Related Concepts

Lung
Dioxygen
Mechanical Ventilation
Critical Illness

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