Are particular Epstein-Barr virus strains linked to disease?

Seminars in Cancer Biology
P J Jenkins, P J Farrell

Abstract

The presence of the well-established EBV types (type 1 and 2) in cancers seems merely to reflect their prevalence in the population; the EBNA genes which determine type 1 and 2 are not usually expressed in cancers. In contrast, LMP1 is frequently expressed in nasopharyngeal carcinoma and a variant form of LMP1 has been linked with this disease. This form of LMP1 is also more transforming in cell culture assays. Many other examples of minor sequence variation have been reported but there is no evidence that they are of functional importance in EBV-associated disease.

Citations

Jan 24, 2002·AIDS Research and Human Retroviruses·Lucia FassoneLuigi Maria Larocca
Jan 1, 2012·Pathogens·Stelios Tzellos, Paul J Farrell
Mar 13, 2014·Journal of Medical Virology·Ying YangBing Luo
Jul 17, 2004·Zhonghua bing li xue za zhi Chinese journal of pathology·Tong-Zhen ChenXiong-Zeng Zhu
Jul 25, 2019·Viral Immunology·Philip G Stevenson
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·M F EssopG Pallesen
Jul 1, 1997·Critical Reviews in Oncology/hematology·H KnechtP Brousset
Mar 16, 2000·Microbes and Infection·B Wensing, P J Farrell

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