Are Pasteurized Autografts Durable for Reconstructions After Bone Tumor Resections?

Clinical Orthopaedics and Related Research
Seung Yong LeeBum Suk Kim

Abstract

Pasteurized autograft is regarded as a biologic reconstructive option for managing bone defects after tumor resection; however, reports on long-term outcomes from large patient series are scarce. Contrary to previous favorable reports, we have observed many patients with failures, in particular as the duration of followup increased. Because pasteurized autografts are used in many countries as a reconstruction option, we wished to formally evaluate patients who underwent this approach at one specialty center. (1) What is the graft survival and what proportion of patients achieved union when pasteurized autografts were used for bone defects after tumor resection? (2) What are the complications and causes of graft removal? (3) What factors are related to the likelihood of union and graft survival? (4) What is the survival and cause of failure by type of pasteurized autograft reconstruction? Over a 26-year period from 1988 to 2013, we performed 1358 tumor resections in our center. Of these, 353 were reconstructed with pasteurized autograft. Other reconstructions included endoprostheses (508 patients), instant arthrodesis using an intramedullary nail and bone cement (286 patients), allografts (97 patients), and resection only (114 p...Continue Reading

References

Jan 1, 1997·The Journal of Bone and Joint Surgery. American Volume·E Ortiz-CruzH J Mankin
Mar 17, 1999·Archives of Orthopaedic and Trauma Surgery·K ShimizuS Shin
Jan 12, 2001·Clinical Orthopaedics and Related Research·F J HornicekH J Mankin
Mar 17, 2004·Clinical Orthopaedics and Related Research·Jun ManabeHiroshi Kuroda
Oct 22, 2005·Clinical Orthopaedics and Related Research·David R MooreHerbert S Schwartz
Mar 1, 2006·Clinical Orthopaedics and Related Research·Mujahid Jamil KhattakMohammad Umar
Dec 6, 2006·Clinical Orthopaedics and Related Research·Dae-Geun JeonSoo-Yong Lee
Aug 8, 2007·Journal of Surgical Oncology·Dae-Geun JeonSoo-Yong Lee
Sep 4, 2007·Clinical Orthopaedics and Related Research·Han-Soo KimSang-Hoon Lee
Nov 28, 2007·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Dae-Geun JeonSoo-Yong Lee
Jun 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiroyuki TsuchiyaKatsuro Tomita
Oct 22, 2010·Archives of Orthopaedic and Trauma Surgery·Ahmed Shawky EidWan Hyeong Cho
Feb 9, 2011·Annals of Plastic Surgery·Yoshihiro NishidaNaoki Ishiguro
Jun 22, 2011·Clinical Orthopaedics and Related Research·Luis Aponte-TinaoD Luis Muscolo
Jul 20, 2011·The Journal of Bone and Joint Surgery. British Volume·M D SewellT W R Briggs
Aug 28, 2012·Archives of Orthopaedic and Trauma Surgery·Hideshi SugiuraKenji Yamada
Oct 26, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shingo ShimozakiHiroyuki Tsuchiya

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Citations

Feb 27, 2021·Journal of Reconstructive Microsurgery·Luis Guilherme Rosifini Alves RezendeEdgard Eduard Engel

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