Are Patients With Schizophrenia Better Off With Lifetime Antipsychotic Medication?: Replication of a Naturalistic, Long-Term, Follow-Up Study of Antipsychotic Treatment.

Journal of Clinical Psychopharmacology
Ira D GlickDanielle Kamis

Abstract

The question of whether people with schizophrenia should be treated with antipsychotics for life has been debated for decades. We recently reported results of 2 retrospective long-term naturalistic studies examining the association of medication adherence and global outcomes in different demographic samples. In both, we found that patients with a history of better adherence to antipsychotic medication had better quality of life outcomes. Using similar methodology, here we present such associations for a very different sample-patients with chronic schizophrenia with a long past history of antipsychotic treatment that had been treated for 19 to 53 years in a Veterans Affairs clinic. This is a retrospective, naturalistic, longitudinal 19- to 53-year (mean average, 33.5 years) lifetime follow-up of a consecutive series of patients with schizophrenia, who had at least 8 years of antipsychotic treatment. Lifetime data were collected on (1) their medication adherence, (2) long-term global outcome, and (3) life satisfaction. Outcomes were rated by 2 different clinicians, one with information on medication adherence (nonblind rater) and one without (blind rater). Linear regression models, adjusted for age, family support, substance use ...Continue Reading

References

Apr 7, 2005·Psychiatric Services : a Journal of the American Psychiatric Association·Stefan TungströmBengt-Ake Armelius
Apr 7, 2007·Psychiatric Services : a Journal of the American Psychiatric Association·Noosha NivAlexander S Young
Nov 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Robin M MurrayDavid Taylor
Feb 16, 2017·Schizophrenia Bulletin·Melissa A WeibellSvein Friis
May 6, 2017·The American Journal of Psychiatry·Donald C GoffJeffrey A Lieberman
Sep 3, 2017·The British Journal of Psychiatry : the Journal of Mental Science·Stefan Leucht, John M Davis
Apr 7, 2018·The American Journal of Psychiatry·Jari TiihonenHeidi Taipale

❮ Previous
Next ❯

Citations

Sep 4, 2020·Current Psychiatry Reports·Philip HensonJohn Torous

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here