Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review

Progress in Neurobiology
Carlos Silva, Neil McNaughton

Abstract

Many see the periaqueductal gray (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal gray that accounts for the distinct characteristics of the area. We provide a comprehensive functional view of the periaqueductal gray, going beyond simple panic and escape to integrate data on fear, anxiety, and depression. Importantly, we conclude that this periaqueductal cluster of nuclei is broadly involved in motivated behavior controlling not only aversive but also appetitive behavior and with some involvement in more complex motivational processes such as approach-avoidance conflict resolution. In sum, these highly conserved nuclei surrounding the aqueduct appear to be the simplest, foundational, elements of integrated motivated goal-directed control of all types.

Citations

Aug 31, 2019·Neurobiology of Stress·Nuria DaviuAnna Beyeler
Nov 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Clara EngelhardtMathias V Schmidt
Sep 4, 2020·CNS Neuroscience & Therapeutics·Chengxi LiuTian Yu
Apr 4, 2021·Neurotoxicology and Teratology·Chela M WallinSusanne Brummelte
May 7, 2021·ELife·Fernando McV ReisAvishek Adhikari
Jun 10, 2021·Scientific Reports·Felix H KlaassenKarin Roelofs
May 18, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Shabah M ShadliNeil McNaughton
May 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin A HughesA Leslie Morrow
Jul 25, 2021·Neuroscience Bulletin·Priscila Vázquez-LeónBruno A Marichal-Cancino
Aug 30, 2021·Biological Psychiatry·Michael A FergusonMichael D Fox

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