Are personalized tongxie formula based on diagnostic analyses more effective in reducing IBS symptoms?-A randomized controlled trial

Complementary Therapies in Medicine
Yuanyuan WangPharm D for the China Irritable Bowel Syndrome Consortium

Abstract

To examine the efficacy and safety ofpersonalized tongxie formulas; to decrease type II errors to minimum. Patients were randomized (1:1:1) into three groups given tongxie, placebo, or pinaverium 3 times daily for 4 weeks. Patients in the tongxie group were treated with personalized formulas based on TCM differential diagnosis, i.e., basic type of IBS, IBS due to liver depression and qi stagnation, excess heat in the liver, deficient spleen function, deficient kidney function, and others (groups 1-6). Primary endpoints were significantly greater reductions in abdominal pain and Bristol stool score. Secondary endpoints were reductions in pain and stool frequencies and abdominal discomfort and its frequency. There were significantly more patients whose stool consistencies were improved than pains were relieved in the entire population (p < 0.001), but there was no significantly difference in subpopulation group 3 (p > 0.05). There were significantly more patients whose stool frequencies were reduced than pain frequencies were reduced in the entire population (p < 0.001), but there were no significantly difference in the subpopulation Groups 1, 3, 4, and 6 (p > 0.05). Multiple active ingredients and their mechanisms of actions to ...Continue Reading

Citations

Nov 2, 2019·Journal of Gastroenterology and Hepatology·Niandi TanYinglian Xiao
Mar 5, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Min ChenHui Zheng

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