Are phospholipid-binding antibodies implicated in the pathogenesis of diabetic microangiopathy?

Medical Hypotheses
C Giusti

Abstract

Diabetic retinopathy (DR) is a major cause of blindness in the working population of the Western world and there is no doubt that its prevalence is strongly related to the duration of diabetes and the glycemic control. However, although intensive diabetes management, with the goal of achieving near-normal glycemia, has been shown to prevent and/or delay the onset of DR, there is now ample of evidence that the development of this microangiopathy is a multifactorial process in which genetic, metabolic, haemostatic and growth factors play an important role. Moreover, given the suggestions that immunological mechanisms might have a role in the pathogenesis of diabetic microangiopathy via immune complex deposition, it has been hypothesized that antiphospholipid antibodies (A-Ab) directed against endothelial antigens could be responsible for initiating vascular injury. In particular, not only A-Ab production was found to be increased in patients with overt nephropathy or macroangiopathy but also Lupus Anticoagulant positivity, representing an intersection point between immune and haemostatic alterations, has been highlighted as a potential and additional risk factor in the pathogenesis of microangiopathy in type 1 diabetics. Moreover...Continue Reading

References

Aug 30, 2002·Metabolism: Clinical and Experimental·Soad M MohamedLamia M Soghier
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Zhigao HuangRonald F Pfeiffer
Aug 14, 2003·European Journal of Pediatrics·Freja EbelingVesa Rasi
Oct 29, 2003·Neurology·D TanneUNKNOWN NINDS rt-PA Stroke Study Group
Nov 5, 2003·Lupus·D M LevyE D Silverman
Dec 4, 2003·American Journal of Ophthalmology·Bettine C P PolakHendrik A Van Leiden
Mar 16, 2004·Pediatric Diabetes·C Giusti

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Citations

Aug 2, 2005·Treatments in Endocrinology·Ricardo P GarayCarlo Chiavaroli
May 4, 2005·Journal of Diabetes and Its Complications·Iván G PalomoMarcela R Vásquez
Jul 1, 2009·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Maha ShahinMohamed Mabed
Apr 9, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mirjana BećarevićSvetlana Ignjatović
Aug 12, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tsunehiko IkedaHidehiro Oku

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