Apr 5, 2020

Are Predator smell (TMT)-induced behavioral alterations in rats able to inhibit seizures?

Chemical Senses
P Delfino-PereiraNorberto Garcia-Cairasco


To evaluate the chemical and behavioral effects of 2,5-Dihydro-2,4,5-trimethylthiazoline (TMT) after olfactory exposure and to verify their influence in the expression of acute audiogenic seizures in the Wistar Audiogenic Rat (WAR) strain. TMT gas chromatography was applied to define odor saturation in a chamber to different concentrations, time required for saturation and desaturation, and if saturation was homogeneous. Also, male adult Wistar rats were exposed to saline (SAL) or to different TMT concentrations and their behaviors were evaluated (neuroethology). Male adult WARs were exposed for 15 seconds (s) to SAL or TMT, followed by sound stimulation for 1 minute (min) or until tonic-clonic convulsion. Behavioral analysis included: latencies (wild running and tonic-clonic convulsion), seizure severity indexes and neuroethology. Gas chromatography established a saturation homogeneous to different concentrations of TMT, indicating that saturation and desaturation occurred in 30 min. TMT triggered fear-like or aversion-like reactions associated to reduction in motor activity and in grooming behavior, in the two highest concentrations. Pure TMT presented anticonvulsant properties, such as less severe seizure phenotype, as well ...Continue Reading

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Mentioned in this Paper

Stimulation Procedure
Protein Expression
Thiol S-methyltransferase Activity
Fear (Mental Process)
Gas Chromatography
Olfactory Nerve
Salinity Response
Aversion (Finding)

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