Are pregnancy-associated plasma protein-A (PAPP-A) and CA 125 measurements after IVF-ET possible predictors of early pregnancy wastage?

Human Reproduction
P BischofL Cédard

Abstract

Pregnancy-associated plasma protein-A (PAPP-A), a macromolecular glycoprotein of placental origin, was reported to be depressed in established ectopic pregnancies. CA 125 is a known marker for ovarian cancer found to be elevated during the first trimester of pregnancy and in women with pelvic inflammatory disease. The present study investigated the usefulness of these parameters to predict the outcome of pregnancy in asymptomatic patients with a positive pregnancy test after in-vitro fertilization and embryo transfer (IVF-ET). Blood samples (n = 159) were obtained at different periods of time post-ET from 39 women, 21 of whom experienced a normal pregnancy, 12 had an intrauterine abortion and six had an ectopic pregnancy. PAPP-A and CA 125 were measured by radioimmunoassays. From day 30 onwards in normal pregnancies, PAPP-A was significantly increased over non-pregnant controls. In the spontaneous abortion group, the levels of PAPP-A were significantly lower than in normal pregnancy but higher than in non-pregnant controls. In ectopic pregnancy, PAPP-A remained at the level of non-pregnant controls throughout the entire observation period. CA 125 was significantly increased in all types of pregnancy. However, in two cases of hy...Continue Reading

Citations

Jun 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F ScarpelliniL Scarpellini
Apr 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P Bischof
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·M R JohnsonK H Nicolaides
Jun 1, 2000·Human Reproduction·M EpineyP Bischof
Sep 12, 2002·Prenatal Diagnosis·Yuval YaronAvi Orr-Urtreger
Feb 28, 2003·American Journal of Reproductive Immunology : AJRI·Sanja VujisićAsim Kurjak
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S NurG Ramaswamy
May 27, 2003·American Journal of Reproductive Immunology : AJRI·Aydin AriciNeal G Mahutte

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