Are psychiatric disorders independent risk factors for new-onset epilepsy in older individuals?

Epilepsy & Behavior : E&B
Alan EttingerMary Jo V Pugh

Abstract

This retrospective study examined whether psychiatric conditions are directly related to epilepsy or, rather, are associated with underlying central nervous system (CNS) disorders linked to subsequent epilepsy. We examined data from a sample of older veterans (>65 years) receiving care from the Veterans Health Administration during fiscal year 2000. We compared individuals with new-onset epilepsy and individuals without epilepsy to examine the extent to which psychiatric disorders were associated with new-onset epilepsy; this analysis controlled for demographic and premorbid neurological risk factors previously associated with new-onset epilepsy. Premorbid psychiatric conditions occurred at higher rates in the epilepsy versus nonepilepsy groups, foremost including depression (17% vs 12%), anxiety (12% vs 8%), psychosis (12% vs 5%), and substance abuse (8% vs 4%). However, in the final model, only psychosis (OR=1.4, CI 1.2-1.6) was significantly associated with epilepsy when controlling for neurological disorders and psychiatric conditions (e.g., stroke, dementia, brain tumor, head injury).

References

Jun 1, 1992·Archives of Neurology·E B BromfieldW H Theodore
May 1, 1990·Epilepsy Research·L Forsgren, L Nyström
May 1, 1989·Epilepsia·B P Hermann, A R Wyler
Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Oct 10, 2003·American Journal of Public Health·Nancy R KressinLewis E Kazis
Sep 29, 2004·Neurology·Alan EttingerUNKNOWN Epilepsy Impact Project Group
May 24, 2005·Epilepsy & Behavior : E&B·Joyce A CramerXiao Xu
Aug 10, 2005·Dementia and Geriatric Cognitive Disorders·Laura L KrishnanMark E Kunik
Aug 24, 2005·Neurology·Alan B EttingerRobert M A Hirschfeld
Sep 24, 2005·Health Services Research·Robert O MorganCarol M Ashton
Oct 12, 2005·Annals of Neurology·Dale C HesdorfferOlafur Kjartansson
Nov 24, 2005·The Journal of Head Trauma Rehabilitation·Ricardo E Jorge, Sergio E Starkstein
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alan B Ettinger, Charles E Argoff
Jan 5, 2007·Epilepsia·Michael SalzbergTerrence J O'Brien
Jun 26, 2007·Biological Psychiatry·Gregor HaslerWilliam H Theodore
Sep 25, 2007·Journal of Neurochemistry·Daniel KondziellaUrsula Sonnewald
Dec 6, 2007·Epilepsia·Siddhartha NadkarniOrrin Devinsky
Feb 1, 2008·Neurosurgery·Andrea Pace, Alfredo Pompili
Mar 5, 2008·Current Opinion in Neurology·Andres M Kanner
Apr 9, 2008·Archives of General Psychiatry·Robert S WilsonDavid A Bennett
May 30, 2008·Neurology·M J V PughUNKNOWN Treatment In Geriatric Epilepsy Research (TIGER) team
Sep 4, 2008·Brain : a Journal of Neurology·A LotheP Ryvlin
Mar 27, 2009·The New England Journal of Medicine·Ashish K JhaDavid Blumenthal

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Citations

Mar 22, 2014·Current Neurology and Neuroscience Reports·Heidi M Munger Clary
Apr 21, 2011·BMC Health Services Research·Laurel A CopelandMary Jo Pugh
Aug 9, 2011·Epilepsy & Behavior : E&B·Christine LinehanAnne T Berg
Sep 21, 2010·Epilepsy & Behavior : E&B·Priscila Camile Barioni SalgadoFernando Cendes
Jan 9, 2016·Journal of Rehabilitation Research and Development·Rizwana RehmanTung T Tran
Feb 25, 2015·Epilepsia·Mary Jo Pugh, Karen Parko
Nov 23, 2013·Epilepsy & Behavior : E&B·Nicol RühleJohannes Rösche
Nov 26, 2013·Epilepsy & Behavior : E&B·Eyal FruchterMark Weiser
Feb 15, 2011·Epilepsy & Behavior : E&B·Anne T BergDale C Hesdorffer
Apr 26, 2015·Epilepsy & Behavior : E&B·Natalie N RohdeMary Jo Pugh
Jul 14, 2011·Nature Reviews. Neurology·Christian Hoppe, Christian E Elger
Sep 27, 2018·Expert Opinion on Pharmacotherapy·Marco Mula
Jul 18, 2018·Journal of Psychiatric Practice·Jennifer L YehlF Andrew Kozel
Jan 31, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A S AvedisovaA B Guekht
Mar 10, 2011·Expert Review of Neurotherapeutics·Ann Johnston, Phil E M Smith

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