PMID: 6721028Mar 1, 1984Paper

Are sperm immobilizing antibodies in cervical mucus an explanation for a poor postcoital test?

American Journal of Reproductive Immunology : AJRI
S JagerI W De Wilde-Janssen

Abstract

Previous authors reported high incidences of complement dependent sperm immobilizing antibodies in cervical mucus (CM) and found a correlation with poor postcoital tests. In all those investigations the CM samples were tested after dilution with a salt solution. In the present study we investigated 50 CM samples from infertile couples who had during the routine fertility investigation poor postcoital tests. All CM samples were tested after dilution with an equal volume of normal human serum; only one sample was found positive. On the other hand, if the CM samples were diluted with an equal volume of a buffered salt solution, many positive results were obtained. With some guinea pig serum batches, however, all tests with buffer-diluted CM samples were negative, despite good reaction of the positive control serum. We concluded that the positive results with buffer-diluted CM samples were due to a factor in the animal serum used as complement preparation and that complement-dependent sperm immobilizing antibodies in CM are an unlikely cause of a poor postcoital test.

References

Mar 1, 1979·Archives of Andrology·R J Hancock
Dec 1, 1978·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W P Wong
Dec 1, 1977·Fertility and Sterility·J Z ScottV Davajan
Feb 1, 1976·Fertility and Sterility·K S Moghissi
Mar 1, 1976·Fertility and Sterility·J Kremer, S Jager
Nov 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·W E Parish, A Ward
Jan 1, 1974·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·J Friberg
Jan 1, 1981·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·H J Ingerslev
Dec 1, 1982·American Journal of Reproductive Immunology : AJRI·H J IngerslevJ Kremer

Citations

Feb 19, 2008·Fertility and Sterility·G N Clarke
Nov 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·G G Haas
Sep 5, 2020·American Journal of Reproductive Immunology : AJRI·Hiroaki ShibaharaAkiko Hasegawa

Related Concepts

Cervix Uteri
Subfertility
Mucous Body Substance
Y-Chromosome-Bearing Sperm

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