Are stable postoperative biliary atresia patients really stable?

Pediatric Surgery International
H KobayashiT Miyano

Abstract

Transforming growth factor-beta 1 (TGF beta-1) is an important mediator of liver-cell proliferation and replication that is implicated in hepatic fibrosis (HF). Hepatic stellate cells (HSC) are activated by TGF beta-1 and are the main precursor cells involved in fibrogenesis. The correlation between serum TGF beta-1, activated HSC in liver-biopsy specimens, and liver biochemistry was investigated to determine the value of TGF beta-1 as an indicator of clinical status in postoperative biliary atresia (BA) patients. Thirty-two postoperative BA patients (mean age 11.2 +/- 2.8 years) and 13 normal controls (mean age 10.3 +/- 3.7 years) were studied. Based on average liver function test (LFT) results over a 3-month period immediately prior to this study, the BA patients were divided into group I (anicteric, normal LFT; n = 10); group II (anicteric, elevated liver transaminases; n = 12), and group III (jaundiced end-stage liver fibrosis awaiting liver transplantation; n = 10). Serum TGF beta-1 was determined using ELISA. Liver-biopsy specimens were examined with antibody against TGF beta-1 and alpha-smooth muscle actin (SMA) antibody for detection of activated HSC. Serum TGF beta-1 was significantly higher in groups I (11.4 +/- 3.7 n...Continue Reading

Citations

Jul 10, 2004·Pediatric Surgery International·N P Sheth
Oct 2, 2004·Pediatric Surgery International·Hiroyuki KobayashiTakeshi Miyano
Feb 9, 2007·Pediatric Surgery International·Tsuyoshi TamuraTakeshi Miyano
Nov 4, 2010·Pediatric Surgery International·Sittisak HonsawekYong Poovorawan
Jul 30, 2008·World Journal of Pediatrics : WJP·Chun ShenXian-Min Xiao
Aug 13, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·María-Mercedes Otero-RivasManuel-Ángel Rodríguez-Prieto
Mar 6, 2004·Seminars in Neonatology : SN·Hiroyuki Kobayashi, Mark D Stringer
Oct 11, 2015·Journal of Pediatric Surgery·Luis Ricardo Longo-SantosUenis Tannuri
Apr 8, 2015·World Journal of Pediatrics : WJP·Zhi-Hong JianJiaan-Der Wang

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