Are studies of motor cortex plasticity relevant in human patients with Parkinson's disease?

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
M BolognaA Berardelli

Abstract

Over the last decade, electrophysiological studies in parkinsonian animals have shown that there are abnormalities of synaptic plasticity in motor areas of cortex and basal ganglia. In humans with Parkinson's disease (PD), cortical plasticity has been widely investigated using transcranial magnetic stimulation. A number of studies have reported abnormal responses to several different conditioning protocols, but their relationship to altered basal ganglia output and dopaminergic loss is still not entirely clear. Thus in the near future it seems unlikely that measures of cortical plasticity could be used as a biomarker of disease severity and progression. In this review we provide an overview on current knowledge of abnormalities of plasticity in PD in the light of recent advances in parkinsonian animal models. Finally we will discuss the relevance of abnormalities of plasticity in the clinical context of PD.

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Citations

Aug 2, 2016·Expert Review of Neurotherapeutics·Antonio SuppaGiovanni Fabbrini
Dec 14, 2019·Brain : a Journal of Neurology·Matteo BolognaAlfredo Berardelli
Jul 18, 2020·Reviews in the Neurosciences·Tommaso SchirinziLuca Marsili
Jun 15, 2018·Brain : a Journal of Neurology·Matteo BolognaAlfredo Berardelli
Aug 28, 2016·Experimental Brain Research·Angel Lago-RodriguezBinith Cheeran
Oct 11, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Daniele BelvisiAlfredo Berardelli
Aug 23, 2020·Annals of Neurology·Chloe Lau-Ha ChungMark Hallett
Apr 2, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Giulia PaparellaMatteo Bologna

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