PMID: 8593930Mar 1, 1996Paper

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

Diabetes
M Prentki, B E Corkey

Abstract

Widely held theories of the pathogenesis of obesity-associated NIDDM have implicated apparently incompatible events as seminal: 1) insulin resistance in muscle, 2) abnormal secretion of insulin, and 3) increases in intra-abdominal fat. Altered circulating or tissue lipids are characteristic features of obesity and NIDDM. The etiology of these defects is not known. In this perspective, we propose that the same metabolic events, elevated malonyl-CoA and long-chain acyl-CoA (LC-CoA), in various tissues mediate, in part, the pleiotropic alterations characteristic of obesity and NIDDM. We review the evidence in support of the emerging concept that malonyl-CoA and LC-CoA act as metabolic coupling factors in beta-cell signal transduction, linking fuel metabolism to insulin secretion. We suggest that acetyl-CoA carboxylase, which synthesizes malonyl-CoA, a "signal of plenty," and carnitine palmitoyl transferase 1, which is regulated by it, may perform as fuel sensors in the beta-cell, integrating the concentrations of all circulating fuel stimuli in the beta-cell as well as in muscle, liver, and adipose tissue. The target effectors of LC-CoA may include protein kinase C sub-types, complex lipid formation, genes encoding metabolic enzym...Continue Reading

Citations

Oct 3, 2000·Journal of Physiology and Biochemistry·E RocheB Soria
Nov 27, 2004·Human Genetics·Michael J RiedelPeter E Light
May 5, 2011·Molecular and Cellular Biochemistry·Heather A HostetlerFriedhelm Schroeder
Jun 21, 2012·Molecular Biology Reports·Qinggang LiChangxin Wu
Mar 9, 2004·Protein Expression and Purification·Demin ZhouGuang Yang
Jul 1, 1997·Journal of the American Dietetic Association·E Ravussin, P A Tataranni
Apr 7, 2000·Molecular Aspects of Medicine·J MercierR Ventura
Jan 4, 2001·Diabetes Research and Clinical Practice·T KawaiT Saruta
Oct 24, 2002·Advanced Drug Delivery Reviews·James M Lenhard, William K Gottschalk
Oct 24, 2000·Trends in Endocrinology and Metabolism : TEM·R N Bergman, M Ader
Nov 17, 2001·Journal of Diabetes and Its Complications·A Piñero-Piloña, P Raskin
Dec 22, 1999·Biochimica Et Biophysica Acta·G F GibbonsR J Pease
Dec 22, 1999·The Proceedings of the Nutrition Society·R G VernonM T Travers
May 7, 1999·The Biochemical Journal·N VoilleyM Prentki
Jan 19, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G G Holz, G Holz
Aug 7, 2008·The Journal of Biological Chemistry·Kevin LaradeH Franklin Bunn
Dec 25, 2003·The Proceedings of the Nutrition Society·E E Blaak
Feb 21, 2006·Antioxidants & Redox Signaling·Gustav Mattiasson, Patrick G Sullivan
Mar 15, 2011·Cardiovascular Research·Christine Des RosiersJohn C Chatham
Mar 1, 2011·Cardiovascular Research·Kedryn K Baskin, Heinrich Taegtmeyer
Jan 31, 1998·The Journal of Clinical Investigation·N BarzilaiL Rossetti

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.