PMID: 589470Dec 9, 1977

Are the dorsal noradrenergic bundle projections from the locus coeruleus important for neocortical or hippocampal activation?

Brain Research
T E RobinsonB A Pappas

Abstract

Three different methods were used to examine the importance of the dorsal noradrenergic bundle projections from the locus coeruleus (LC) in activation of the neocortex and hippocampus in freely moving rats. (1) After cerebral norepinephrine (NE) was depleted by systemic neonatal injections of 6-hydroxydopamine (6-OHDA) both atropine-resistant and atropine-sensitive forms of hippocampal rhythmical slow activity (RSA; theta) and neocortical low voltage fast activity (LVFA) remained intact. Compared to controls the adult rats treated with 6-OHDA in infancy reared less in a 24 h time sample of behavior and ran less in running wheels. (2) Brain dopamine and NE were also depleted by systemic injections of alpha-methyl-p-tyrosine. Following this treatment rats were very inactive behaviorally. However, normal activation of the hippocampus and neocortex was still present. (3) In normal rats, electrical stimulation of the LC was relatively ineffective, compared to stimulation of nucleus reticularis pontis caudalis, in producing behavioral changes (especially locomotion) or either atropine-resistant or atropine-sensitive hippocampal RSA or neocortical LVFA. It is concluded that the locus coeruleus is not important for cerebral activation,...Continue Reading

References

May 1, 1976·Electroencephalography and Clinical Neurophysiology·T PaivaW Mollevanger
Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·B A PappasB Drew
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
May 1, 1974·Journal of Comparative and Physiological Psychology·T E Robinson, I Q Whishaw
Jul 1, 1971·Canadian Journal of Physiology and Pharmacology·J P CordeauB Jacks
Aug 12, 1970·Brain Research·P Polc, M Monnier
May 1, 1968·International Journal of Neuropharmacology·R P MaickelF P Miller

Citations

Jan 1, 1982·Neuroscience and Behavioral Physiology·V A Markevich, L L Voronin
Oct 1, 1978·Neuropharmacology·M Saari, B A Pappas
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·C H VanderwolfG B Baker
Jul 1, 1979·Brain Research·S T Mason, S D Iversen
Aug 1, 1985·Behavioural Brain Research·L J Ryan
Jan 1, 1982·Progress in Neurobiology·R P Vertes
Jan 1, 1984·Progress in Neurobiology·R P Vertes
Jan 1, 1986·Progress in Neurobiology·B H Bland
Jan 1, 1991·Brain Research Bulletin·A J Heynen, R S Sainsbury
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N KönigA Szafarczyk
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A ValjakkaP J Riekkinen
Apr 1, 1979·Behavioral and Neural Biology·P Ramm
Jul 1, 1980·Behavioral and Neural Biology·D Garrigou, D Blozovski
Mar 1, 1984·Behavioral and Neural Biology·G Fontani, F Farabollini
Nov 1, 1980·Electroencephalography and Clinical Neurophysiology·T E Robinson, D J Green
Aug 4, 1980·Brain Research·D P Friedman, F E Horvath
Aug 31, 2014·Progress in Neurobiology·L S LeungIan Herrick
May 21, 2010·The International Journal of Neuropsychopharmacology·Charles H K West, Jay M Weiss

Related Concepts

Atropen
Brain Stem
Cerebellum
Insula of Reil
Motor Pathways
Electroencephalogram
FLA 63
Structure of Subiculum Hippocampi
Hydroxydopamine
Hydroxyindoleacetic Acid

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