Are the MDS-UPDRS-Based Composite Scores Clinically Applicable?

Movement Disorders : Official Journal of the Movement Disorder Society
Attila MakkosNorbert Kovács

Abstract

The International Parkinson and Movement Disorder Society-sponsored UPDRS (MDS-UPDRS) is a powerful clinical outcome measure. To evaluate the feasibility of various MDS-UPDRS-based composite scores and determine their minimal clinically important difference threshold values. Overall, 1,113 paired investigations of 452 patients were reviewed implementing three different techniques simultaneously. Based on the ordinal regression modeling, the MDS-UPDRS II+III, MDS-UPDRS I+II+III, and the total score of MDS-UPDRS are clinically applicable outcome measures. Any improvement greater than 4.9 points or any worsening more than 4.2 points on MDS-UPDRS II+III represent a minimal, yet clinically meaningful, change. In reference to MDS-UPDRS I+II+III, the smallest changes considered clinically relevant were 6.7 and 5.2 points for improvement and deterioration, respectively. The thresholds for the total score of MDS-UPDRS were 7.1 points for improvement and 6.3 points for worsening. Our findings support the application of various MDS-UPDRS-based composite scores. © 2018 International Parkinson and Movement Disorder Society.

References

Dec 1, 1989·Controlled Clinical Trials·R JaeschkeG H Guyatt
Oct 27, 2001·Archives of Neurology·J Jankovic, A S Kapadia
Dec 21, 2002·Archives of Neurology·UNKNOWN Parkinson Study Group
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease
May 5, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Anette SchragWerner Poewe
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Jan 13, 2010·Archives of Neurology·Lisa M ShulmanWilliam J Weiner
Jul 10, 2010·The International Journal of Neuroscience·Philip O BuckJamie Clark
Mar 26, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Robert A HauserUNKNOWN Parkinson Study Group
May 22, 2013·Computational Intelligence and Neuroscience·Julien StamatakisGaëtan Garraux
Jun 25, 2013·Parkinsonism & Related Disorders·Carmen Rodriguez-BlazquezPablo Martinez-Martin
Oct 15, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Anthony E LangUNKNOWN LABS-PD investigators
Feb 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Rajesh PahwaMary Jean Stempien
Mar 12, 2015·Journal of Parkinson's Disease·Gabriella DeliNorbert Kovács
Jun 2, 2015·Orvosi hetilap·Tivadar LuczaNorbert Kovács
Jun 17, 2015·Behavioural Neurology·Tivadar LuczaNorbert Kovács
Nov 19, 2015·Parkinsonism & Related Disorders·Krisztina HorváthNorbert Kovács
Nov 23, 2015·International Journal of Clinical Pharmacy·Martina Henrichsmann, Georg Hempel
Feb 19, 2016·Journal of Parkinson's Disease·Rita WeintrautNorbert Kovács
Feb 22, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Krisztina HorváthNorbert Kovács
Apr 10, 2017·European Neurology·Annamária JuhászNorbert Kovács

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Citations

Jan 15, 2021·Scientific Reports·Gabriella HernadiGabor Perlaki
Mar 4, 2019·Parkinsonism & Related Disorders·Sara MeoniElena Moro
Nov 26, 2021·Stereotactic and Functional Neurosurgery·Jeroen G V HabetsMarcus L F Janssen

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