Are the renal effects of lithium modified by frequency of administration?

Acta Psychiatrica Scandinavica
G AbrahamJ S Lawson

Abstract

It has been claimed that the unwanted effects and toxicity of lithium can be minimized by changes in the dosing schedules. Twenty consecutive psychiatrically stable patients were investigated in a cross-over study to determine whether renal function and other biochemical tests change significantly with changes from once to twice or multiple doses per day or vice versa. There were no significant differences between the 3 study conditions on the mood rating scales or a side effect scale (UKU). Urine volume, test of renal function and other biochemical and hematological indices were similar in all study conditions. We thus conclude that dosing strategy does not consistently affect renal function in lithium-treated patients.

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Citations

Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman
Oct 30, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Lorie CarterAndrea Lewczyk
Jun 5, 2001·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·R S McIntyreS H Kennedy
Sep 17, 2020·Journal of Psychiatric Practice·Virginia FernandesGregory Chandler
Dec 16, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tessa S SchootAngèle P M Kerckhoffs

Related Concepts

Manic Disorder
Melancholia
Dose-Response Relationship, Drug
Drug Administration Schedule
Kidney
Kidney Function Tests
Priadel
Cross-Over Studies

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