PMID: 16527062Mar 11, 2006Paper

Are the Spanish hypertensive children therapeutic orphans?

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
C Morales-CarpiF J Morales-Olivas

Abstract

According to current guidelines, hypertension in children should be treated with the same drugs as those used in adults, with adjustment of the dose to their body size. The term therapeutic orphans refers to the lack of information on how to use drugs in children. The aim of this study was to investigate whether the information in the International Vademecum (I-V) is sufficient for the correct use of antihypertensive drugs in children. We reviewed the data on pediatric dosages of antihypertensive drugs in the I-V (44th and 45th editions). When there were several drugs for the same molecule, the last one marked with the Spanish Ministry of Health and Consumption's logo was selected. When information on a particular drug was not available, the entries for other drugs with the same active principle were reviewed. The information was compared with that provided by the Fourth Report of the National High Blood Pressure Education Program Working Group (NHBPEP). A total of 111 entries for 41 antihypertensive drugs were reviewed. Information on use in children is available for only 3 diuretics and 2 angiotensin converting enzyme inhibitors. The remaining entries either contain no information or indicate that the effectiveness and safety...Continue Reading

Citations

Nov 26, 2009·European Journal of Clinical Pharmacology·Cristina Morales-CarpiFrancisco J Morales-Olivas

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