Are therapeutic diets an emerging additional choice in autism spectrum disorder management?

World Journal of Pediatrics : WJP
M Gogou, G Kolios

Abstract

A nutritional background has been recognized in the pathophysiology of autism and a series of nutritional interventions have been considered as complementary therapeutic options. As available treatments and interventions are not effective in all individuals, new therapies could broaden management options for these patients. Our aim is to provide current literature data about the effect of therapeutic diets on autism spectrum disorder. A systematic review was conducted by two reviewers independently. Prospective clinical and preclinical studies were considered. Therapeutic diets that have been used in children with autism include ketogenic and gluten/casein-free diet. We were able to identify 8 studies conducted in animal models of autism demonstrating a beneficial effect on neurophysiological and clinical parameters. Only 1 clinical study was found showing improvement in childhood autism rating scale after implementation of ketogenic diet. With regard to gluten/casein-free diet, 4 clinical studies were totally found with 2 of them showing a favorable outcome in children with autism. Furthermore, a combination of gluten-free and modified ketogenic diet in a study had a positive effect on social affect scores. No serious adverse ...Continue Reading

References

Oct 21, 1998·Developmental Neuroscience·Y Daikhin, M Yudkoff
Aug 10, 2002·Nutritional Neuroscience·A M KnivsbergM Nødland
Apr 16, 2003·Journal of Child Neurology·Athanasios EvangeliouJan Smeitink
Apr 24, 2003·Journal of Autism and Developmental Disorders·Sarah AldredRosemary H Waring
Sep 10, 2005·Epilepsy Currents·Michael S Duchowny
Mar 24, 2006·Journal of Autism and Developmental Disorders·Jennifer Harrison ElderLindsay Sherrill
May 19, 2007·Pediatric Neurology·Adam L HartmanMichael A Rogawski
Nov 27, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jennifer Harrison Elder
Jun 30, 2011·Journal of Autism and Developmental Disorders·Rabindra TirouvanziamAntonio Y Hardan
May 15, 2013·Journal of Child Neurology·Martha R Herbert, Julie A Buckley
May 22, 2013·Clinical Therapeutics·Timothy Buie
Jun 12, 2013·PloS One·David N RuskinSusan A Masino
Apr 3, 2014·Gastroenterology Research and Practice·Stephen J Genuis, Rebecca A Lobo
May 3, 2014·Journal of Child Neurology·Salvador Marí-BausetMaría Morales-Suárez-Varela
Jul 9, 2014·Nutrition Research Reviews·Marijke M H van De SandeFred J P H Brouns
Jul 30, 2014·Frontiers in Pediatrics·Eleonora NapoliCecilia Giulivi
Aug 5, 2014·Nutritional Neuroscience·Kamila CastroIngrid Schweigert Perry
Jul 17, 2015·Advances in Nutrition·Sobhana Ranjan, Jennifer A Nasser
Sep 8, 2015·Journal of Autism and Developmental Disorders·Susan L HymanTristram Smith
Sep 24, 2015·Nature Reviews. Gastroenterology & Hepatology·Jacalyn A SeeJoseph A Murray
Sep 30, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Klaus W LangeAndreas Reissmann
Jan 20, 2016·European Journal of Clinical Investigation·Ana F BrancoTeresa Cunha-Oliveira
Aug 17, 2016·Autism Research : Official Journal of the International Society for Autism Research·Richelle Mychasiuk, Jong M Rho
Nov 4, 2016·Journal of Autism and Developmental Disorders·Justin B LeafUNKNOWN Autism Partnership Foundation
Nov 15, 2016·Expert Review of Neurotherapeutics·Alberto VerrottiGiangennaro Coppola
Dec 30, 2016·Annals of Agricultural and Environmental Medicine : AAEM·Marzena Ułamek-KoziołStanisław J Czuczwar
Feb 13, 2017·European Child & Adolescent Psychiatry·Verena LyNanda N Rommelse
Mar 24, 2017·Molecular Autism·Amirhossein ModabberniaAbraham Reichenberg
Apr 4, 2017·British Journal of Pharmacology·Lucie P PellissierJulie Le Merrer
Jun 18, 2017·Physiology & Behavior·Daniela Kasprowska-LiśkiewiczJarosław J Barski
Dec 1, 2017·Briefings in Bioinformatics·Nikolas DovrolisIoanna Maroulakou
Dec 27, 2017·Life Sciences·Yongshou YangBo Yang
Sep 28, 2015·Pediatric Health, Medicine and Therapeutics·Jolanta Wasilewska, Mark Klukowski

❮ Previous
Next ❯

Citations

Jul 19, 2019·Journal of the American College of Nutrition·Maria Gogou, George Kolios
Dec 27, 2019·Nutrition Reviews·Elisa KarhuAdrien A Eshraghi
Jul 23, 2020·Autism Research : Official Journal of the International Society for Autism Research·Caitlin C ClementsMarley W Watkins
Apr 18, 2020·Health and Quality of Life Outcomes·Gian Loreto D'AlòUNKNOWN ISACA guideline working group
May 10, 2020·International Journal of Molecular Sciences·Younghee AhnTimothy E Shutt
Jun 21, 2018·World Journal of Pediatrics : WJP·Zhi-Wei ZhuXiao-Lin Liu
Dec 29, 2020·Expert Review of Gastroenterology & Hepatology·Carlo Romano SettanniAntonio Gasbarrini
May 29, 2021·Frontiers in Pediatrics·Qinrui LiJiong Qin
Jun 3, 2021·Foods·Abdul-Hamid M EmwasJoanna Izabela Lachowicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.