PMID: 21033228Nov 3, 2010Paper

Are there any functional differences of the enteric nervous system between jejunum and ileum in normal humans?

Ryouichi TomitaTakeshi Kusafuka


Functional differences of the enteric nervous system (ENS) between the jejunum and ileum in humans are still unknown. To clarify the physiological differences of the ENS in the normal human jejunum and ileum, we investigated the enteric nerve responses on normal jejunum and normal ileum in vitro. Twenty-two preparations of normal jejunum were taken from 22 patients with gastric cancer (14 men and 8 women, aged 43 to 65 years with a mean age of 49.0 years). Twenty preparations of normal ileum were also taken from 20 patients with right sided colonic cancer (15 men and 5 women, aged 40 to 63 years with a mean age of 50.9 years). A mechanographic technique was used to evaluate in vitro muscle responses to electrical stimulation (EFS) of adrenergic and cholinergic nerves before and after treatment with various autonomic nerve blockers. Responses to EFS before blockade of the adrenergic and cholinergic nerves; Muscle strips in jejunum and ileum demonstrated significant contraction reactions rather than relaxation reactions (p < 0.0001, p = 0.0001, respectively). In addition, jejunal muscle strips showed significant contraction reactions than those in ileal muscle strips (p = 0.0274). Responses to EFS after blockade of the adrenergic...Continue Reading

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