Are there gap junctions without connexins or pannexins?

BMC Evolutionary Biology
Georgy A Slivko-KoltchikY Panchin

Abstract

Gap junctions (GJ) are one of the most common forms of intercellular communication. GJs are assembled from proteins that form channels connecting the cytoplasm of adjacent cells. They are considered to be the main or the only type of intercellular channels and the universal feature of all multicellular animals. Two unrelated protein families are currently considered to be involved in this function, namely, connexins and pannexins (pannexins/innexins). Pannexins were hypothesized to be the universal GJ proteins of multicellular animals, distinct from connexins that are characteristic of chordates only. Here we have revised this supposition by applying growing high throughput sequencing data from diverse metazoan species. Pannexins were found in Chordates, Ctenophores, Cnidarians, and in the most major groups of bilateral protostomes. Yet some metazoans appear to have neither connexins nor pannexins in their genomes. We detected no connexins or pannexins/innexins homologues in representatives of all five classes of echinoderms and their closest relatives hemichordates with available genomic sequences. Despite this, our intracellular recordings demonstrate direct electrical coupling between blastomeres at the 2-cell embryo of the ...Continue Reading

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Citations

May 7, 2020·Frontiers in Neuroanatomy·E Anne MartinAdam C Miller
Mar 1, 2019·BMC Evolutionary Biology·Yuriy L OrlovLeonid L Moroz
Feb 9, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Leonid L MorozAndrea B Kohn
Jun 3, 2021·International Journal of Molecular Sciences·Nariman BattulinYuri Panchin
Jan 20, 2022·ELife·Georg Welzel, Stefan Schuster

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Methods Mentioned

BETA
dissection

Software Mentioned

Excel
BLASTP
HMMER
BLAST
SigmaPlot
pCLAMP
TBLASTN

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