PMID: 2512198Jan 1, 1989Paper

Are there morphologically abnormal early recombination nodules in the Drosophila melanogaster meiotic mutant mei-218?

Genome Génome / Conseil National De Recherches Canada
A T Carpenter

Abstract

Early recombination nodules have been suggested to perform a role in meiotic gene conversion recombination events. The meiotic recombination-defective mutant mei-218 greatly reduces the frequency of meiotic crossover (reciprocal) recombination events and reduces the number of late recombination nodules to the same extent. However, it does not reduce the frequency of simple gene conversion events, although they are abnormal in having shorter coconversion tracts than controls. The original cytological study yielded somewhat fewer early nodules in mei-218 than in controls, although very abnormal ones might have been missed. The present study failed to identify a mei-218 specific abnormal category. However, because recombination nodules are at present recognizable only by their morphology, a definitive answer to this question must await a specific probe for recombination nodules. Moreover, the possibility remains that early nodules in mei-218 are more ephemeral than are early nodules in wild type.

Citations

Feb 18, 2012·Annual Review of Physiology·Cathleen M Lake, R Scott Hawley
Nov 14, 2002·Annual Review of Genetics·Kim S McKimElizabeth A Manheim
Feb 26, 2000·Annual Review of Genetics·D Zickler, N Kleckner
Aug 13, 2005·Progress in Nucleic Acid Research and Molecular Biology·S Anuradha, K Muniyappa
Aug 4, 2016·Frontiers in Cell and Developmental Biology·Alphy JohnJishy Varghese
Feb 3, 2007·BioTechniques·Michael R LamprechtAnne E Carpenter
Apr 3, 2020·Molecular Imaging·Asmaysinh GhariaMekhail Anwar

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