Abstract
Despite its frequency and high functional impact, very little is known about effective strategies for managing cognitive impairment in multiple sclerosis (MS). Disease-modifying drugs, such as beta-interferons and glatiramer acetate, may prevent or reduce the progression of cognitive dysfunction by containing the development of new cerebral lesions. To date, clinical trials have provided inconsistent results, with neuropsychological effects documented only in one trial. Moreover, pilot studies have tested symptomatic therapies for fatigue, a frequent symptom in MS, which may share a common physiopathological substrate with cognitive dysfunction. Small trials with amantadine, pemoline, 4-aminopyridine and 3-4 aminopyridine have provided mainly negative results. Acetylcholinesterase inhibitors (AChEI) used to treat Alzheimer's disease (AD)-such as donepezil, rivastigmine, and galantamine-have recently been tested in other cognitive disorders, including MS. The majority of pilot trials with AchEI in MS have provided promising results, and the donepezil study recently published by Krupp et al. represents a major development in this field. As for non-pharmacological interventions based on cognitive rehabilitation, few studies have u...Continue Reading
References
May 1, 1991·Neurology·S M RaoF Unverzagt
Jun 1, 1989·Archives of Neurology·R A Cohen, M Fisher
Jul 1, 1995·Neurology·K P JohnsonR B Schiffer
Sep 1, 1994·Neurology·R C SmitsC H Polman
Feb 1, 1996·Archives of Neurology·M W GeislerL B Krupp
Dec 1, 1996·Neurology·C T BeverK P Johnson
Dec 1, 1996·Neurology·N H PliskinB G Arnason
Apr 6, 1999·Archives of Neurology·A WeinsteinS I Schwid
Jan 11, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·N B LincolnE D Playford
Jan 25, 2002·Multiple Sclerosis : Clinical and Laboratory Research·P M RossiniC Caltagirone
Jan 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·K W RammohanH N Nagaraja
Jan 23, 2002·European Neurology·Yoram Barak, Anat Achiron
Nov 10, 2004·Neurology·L B KruppL E Elkins
Jan 25, 2005·Lancet Neurology·Maria Pia Amato
Citations
May 16, 2007·Journal of Neurology·Alexander WinkelmannUwe K Zettl
Aug 22, 2012·Journal of Clinical and Experimental Neuropsychology·Brian M Sandroff, Robert W Motl
Oct 19, 2013·PloS One·Francesco PattiUNKNOWN COGIMUS Study Group
Mar 13, 2010·International Review of Psychiatry·Epameinondas LyrosPanagiotis Papathanasopoulos
Jun 5, 2012·Revue neurologique·C BensaUNKNOWN Multiple Sclerosis Think Tank (Groupe de reflexion sur la sclerose en plaques GRESEP)
Sep 12, 2009·Revue neurologique·H BrissartM Debouverie
Aug 8, 2008·Journal of Neuroimmunology·Talma BrennerItzhak Wirguin
Apr 1, 2008·Archives of Physical Medicine and Rehabilitation·Amanda R O'BrienJohn Deluca
May 1, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cinthia M MazzantiMaria Rosa C Schetinger
Nov 21, 2008·Journal of Neuroscience Research·Akvile NorkuteMarkus Kipp
Jun 12, 2010·Neurobiology of Aging·Taher Darreh-ShoriAgneta Nordberg
Jan 1, 2014·Multiple Sclerosis and Related Disorders·Brian M SandroffRobert W Motl
Jul 23, 2016·Neuropsychology Review·Brian M SandroffJohn DeLuca
Sep 2, 2016·Acta Neurologica Scandinavica·M MückschelT Ziemssen
Oct 25, 2016·Journal of the Neurological Sciences·Manuel E HernandezRobert W Motl
Aug 24, 2010·Arquivos de neuro-psiquiatria·Maria Lúcia Brito Ferreira
Sep 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·F Patti
Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·F PattiUNKNOWN COGIMUS Study Group
Jun 21, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Robert W MotlRalph H B Benedict
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·B DuqueP Villoslada
Jan 1, 2009·Therapeutic Advances in Neurological Disorders·Ida S HaussleiterGeorg Juckel
Mar 1, 2009·Therapeutic Advances in Neurological Disorders·Francesco PattiMaria Trojano
Nov 30, 2012·Neurorehabilitation and Neural Repair·Antonio CerasaAldo Quattrone
Dec 18, 2013·The Cochrane Database of Systematic Reviews·Dian HeHongyu Zhou
Jun 27, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·D BrunoM Roca
Nov 1, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Vahid ShaygannejadNaser Zakizade